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Clinical Trials/CTRI/2023/10/059333
CTRI/2023/10/059333Not yet recruitingNot Applicable

Evaluation of Neutrophil to Lymphocyte (NLR),Platelet to lymphocyte (PLR) and Lymphocyte to Monocyte (LMR) ratios in peripheral blood of patients having periodontitis with type 2 diabetes mellitus before and one month after scaling and root planing

Dr. Nikita Vikasrao Palkar1 site in 1 country63 target enrollmentStarted: November 25, 2023Last updated:
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Trial Snapshot

Phase
Not Applicable
Status
Not yet recruiting
Sponsor
Enrollment
63
Locations
1
Primary Endpoint
changes in blood cell ratios
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

NLR,PLR,LMR ratios is  useful in the prediction and the detection of inflammatory and infectious conditions, and their postoperative complications. They  also reflects the degree of systemic inflammation, can be consider as prognostic markers.

Hence this study is focused on analysis of the blood cell ratios in periodontitis patients with and without diabetes mellitus before and after scaling and root planing.

Study Design

Study Type
Interventional
Allocation
Adaptive randomization, such as minimization
Masking
Not Applicable

Eligibility Criteria

Ages
20.00 Year(s) to 60.00 Year(s) (—)
Sex
All

Inclusion Criteria

  • •Group A 1.Subjects with clinically healthy periodontium, with no attachment loss and probing depth of less than or equal to 3 mm, <10%bleeding sites, subject with gingival index score of maximum up to <1, included which were considered to be relatively healthy and subject having HbA1c level between 4%–6% considered as control group.
  • •2.Group B: 1.Patients with Periodontitis stage II and stage III as per the 2017 American Academy of Periodontology Classification.
  • •2.Patients with periodontitis stage II having clinical attachment loss of 3-4mm and maximum probing pocket depth ≤5 mm.
  • •3.Patients with periodontitis stage III having clinical attachment loss of ≥5 mm and maximum probing pocket depth ≥ 6mm.35 3.Group C: 1.Patients with periodontitis (stage II and stage III as per the 2017 American Academy of Periodontology classification) with diagnosed case of type 2 diabetes mellitus (Good diabetes control, HbA1c level 7%).

Exclusion Criteria

  • •1.Patient refusal 2.Patient who has received periodontal treatment in last 6months.
  • •3.Patient who is smoker or consuming any other form of tobacco.
  • •4.Pregnant, lactating or postmenopausal women.
  • •5.Hospitalized patients.
  • •6.Subjects consuming antibiotic or other drugs in the past 6 months that affect their periodontal status.
  • •7.History of any systemic disease which influences the values of NLR, PLR, and LMR ratio like any malignancy, cardiovascular diseases, rheumatic diseases, bipolar disorder, thyrotoxicosis, psoriasis other than type 2 diabetes mellitus for the test group (Group III) 8.History of any systemic disease for the control group.
  • •9.If subject cannot maintain oral hygiene after non-surgical periodontal therapy (Gingival index score >1, plaque index>1).

Outcomes

Primary Outcomes

changes in blood cell ratios

Time Frame: one month

Secondary Outcomes

  • Plaque index ,gingival index, probing pocket depth(one month)

Investigators

Sponsor
Dr. Nikita Vikasrao Palkar
Sponsor Class
Other [self]

Study Sites (1)

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