Evaluation of blood cell ratios in periodontitis patients with and without Type 2 Diabetes Mellitus Before and one month after scaling and root planing

Not yet recruiting

• Conditions: periodontitis patients with or without diabetes mellitus; Chronic periodontitis,

• Registration Number: CTRI/2023/10/059333
• Lead Sponsor: Dr. Nikita Vikasrao Palkar

Brief Summary

NLR,PLR,LMR ratios is  useful in the prediction and the detection of inflammatory and infectious conditions, and their postoperative complications. They  also reflects the degree of systemic inflammation, can be consider as prognostic markers.

Hence this study is focused on analysis of the blood cell ratios in periodontitis patients with and without diabetes mellitus before and after scaling and root planing.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-10-30
• Study Start: 2023-11-25

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 63

Inclusion Criteria

• Group A 1.Subjects with clinically healthy periodontium, with no attachment loss and probing depth of less than or equal to 3 mm, <10%bleeding sites, subject with gingival index score of maximum up to <1, included which were considered to be relatively healthy and subject having HbA1c level between 4%–6% considered as control group.
• 2.Group B: 1.Patients with Periodontitis stage II and stage III as per the 2017 American Academy of Periodontology Classification.
• 2.Patients with periodontitis stage II having clinical attachment loss of 3-4mm and maximum probing pocket depth ≤5 mm.
• 3.Patients with periodontitis stage III having clinical attachment loss of ≥5 mm and maximum probing pocket depth ≥ 6mm.35 3.Group C: 1.Patients with periodontitis (stage II and stage III as per the 2017 American Academy of Periodontology classification) with diagnosed case of type 2 diabetes mellitus (Good diabetes control, HbA1c level 7%).

Exclusion Criteria

• 1.Patient refusal 2.Patient who has received periodontal treatment in last 6months.
• 3.Patient who is smoker or consuming any other form of tobacco.
• 4.Pregnant, lactating or postmenopausal women.
• 5.Hospitalized patients.
• 6.Subjects consuming antibiotic or other drugs in the past 6 months that affect their periodontal status.
• 7.History of any systemic disease which influences the values of NLR, PLR, and LMR ratio like any malignancy, cardiovascular diseases, rheumatic diseases, bipolar disorder, thyrotoxicosis, psoriasis other than type 2 diabetes mellitus for the test group (Group III) 8.History of any systemic disease for the control group.
• 9.If subject cannot maintain oral hygiene after non-surgical periodontal therapy (Gingival index score >1, plaque index>1).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
changes in blood cell ratios	one month

Secondary Outcome Measures

Name	Time	Method
Plaque index ,gingival index, probing pocket depth	one month

Trial Locations

Locations (1)

Maharashtra Institute of Dental Sciences and Research Dental College, Latur; 🇮🇳 Latur, MAHARASHTRA, India

Maharashtra Institute of Dental Sciences and Research Dental College, Latur

🇮🇳Latur, MAHARASHTRA, India

Dr Vishnudas Bhandari

Principal investigator

9823525229

vishnudas.bhandari@mitmidsr.edu.in