CTRI/2023/10/059333尚未招募不适用
Evaluation of Neutrophil to Lymphocyte (NLR),Platelet to lymphocyte (PLR) and Lymphocyte to Monocyte (LMR) ratios in peripheral blood of patients having periodontitis with type 2 diabetes mellitus before and one month after scaling and root planing
Dr. Nikita Vikasrao Palkar1 个研究点 分布在 1 个国家目标入组 63 人开始时间: 2023年11月25日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 63
- 试验地点
- 1
- 主要终点
- changes in blood cell ratios
研究概览
简要总结
NLR,PLR,LMR ratios is useful in the prediction and the detection of inflammatory and infectious conditions, and their postoperative complications. They also reflects the degree of systemic inflammation, can be consider as prognostic markers.
Hence this study is focused on analysis of the blood cell ratios in periodontitis patients with and without diabetes mellitus before and after scaling and root planing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Adaptive randomization, such as minimization
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Group A 1.Subjects with clinically healthy periodontium, with no attachment loss and probing depth of less than or equal to 3 mm, <10%bleeding sites, subject with gingival index score of maximum up to <1, included which were considered to be relatively healthy and subject having HbA1c level between 4%–6% considered as control group.
- •2.Group B: 1.Patients with Periodontitis stage II and stage III as per the 2017 American Academy of Periodontology Classification.
- •2.Patients with periodontitis stage II having clinical attachment loss of 3-4mm and maximum probing pocket depth ≤5 mm.
- •3.Patients with periodontitis stage III having clinical attachment loss of ≥5 mm and maximum probing pocket depth ≥ 6mm.35 3.Group C: 1.Patients with periodontitis (stage II and stage III as per the 2017 American Academy of Periodontology classification) with diagnosed case of type 2 diabetes mellitus (Good diabetes control, HbA1c level 7%).
排除标准
- •1.Patient refusal 2.Patient who has received periodontal treatment in last 6months.
- •3.Patient who is smoker or consuming any other form of tobacco.
- •4.Pregnant, lactating or postmenopausal women.
- •5.Hospitalized patients.
- •6.Subjects consuming antibiotic or other drugs in the past 6 months that affect their periodontal status.
- •7.History of any systemic disease which influences the values of NLR, PLR, and LMR ratio like any malignancy, cardiovascular diseases, rheumatic diseases, bipolar disorder, thyrotoxicosis, psoriasis other than type 2 diabetes mellitus for the test group (Group III) 8.History of any systemic disease for the control group.
- •9.If subject cannot maintain oral hygiene after non-surgical periodontal therapy (Gingival index score >1, plaque index>1).
结局指标
主要结局
changes in blood cell ratios
时间窗: one month
次要结局
- Plaque index ,gingival index, probing pocket depth(one month)
研究者
研究点 (1)
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