BBB Imaging and Genomics for Vascular RIsk STudy of Alzheimer Dementia
- Conditions
- Diseases of the nervous system
- Registration Number
- KCT0003181
- Lead Sponsor
- Konkuk University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 88
1)Patients with Dementia due to AD or MCI due to AD (intermediate to high biomarker probability) according to the NIA-AA diagnostic guidelines (2011).Informed consent before participation in the study
2)In case of patient with dementia, Clinical dementia rating (CDR) of 0.5 or 1, which means a mild stage of dementia
3)Age of 45-80
4)Informed consent understood, signed and patient agrees to all follow-up visits.
1) Contraindications for scanning (e.g. brain surgery, cardiac pacemaker, metal implants, claustrophobia, large body tattoos)
2) Contraindications for contrast agent Gadovist (renal failure) as determined by the estimated Glomular Filtration Rate eGFR < 30 mL/min.
3) Major vascular disorders (e.g. stroke, heart disease)
4) Psychiatric or neurological disorders: Major depression (< 12 months); history of schizophrenia; bipolar disorder; psychotic disorder NOS or treatment for a psychotic disorder (< 12 months); cognitive impairment due to alcohol abuse; epilepsy; Parkinson's disease; MS; brain surgery; brain trauma; electroshock therapy; kidney dialysis; Meniere's disease; and brain infections.
5) Structural abnormalities of the brain
6) Cognitive impairment due to alcohol/drug abuse
7) Absence of reliable informant (for patient groups)
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method blood brain barrier permeability as measured by T1-weighted DCE MRI
- Secondary Outcome Measures
Name Time Method temporal change of blood brain barrier permeability as measured by T1-weighted DCE MRI