Cerebellar dysfunction and its compensation in presymptomatic carriers of dominant ataxia genes

Recruiting

• Conditions: Cerebellar ataxia; coordination diffulties; 10028037

• Registration Number: NL-OMON34216
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

Proven mutation in one of the SCA genes
Age > 18 years
Free of ataxia

Exclusion Criteria

Contraindications for MRI scanning (e.g. pacemaker)
Epilepsy
Other neurological disorders
Gait disorder for any reason

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The various studies that are part of this project focus on demonstrating<br /><br>differences in the:<br /><br>-percentage of conditioned eye blink responses<br /><br>-adaptation to splitbelt gait paradigm<br /><br>-motor cortex excitability<br /><br>-cerebellar modulation of motor cortex excitability<br /><br>-structural connection in cerebellum-motor cortex pathway<br /><br>-brain areas involved in the control of gait</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>