The evaluation of the cerebellar symptoms in patients with opsoclonus myoclonus syndrome diagnosed and treated at the Sophia*s Children*s hospital

• Conditions: Dancing-eyes-and-feet syndrome; Opsoclonus Myoclonus Syndrome; 10007951

• Registration Number: NL-OMON47850
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

All patients with OMS, diagnosed and treated at the Sophia Children*s Hospital will be included. OMS is defined as the presence of *3 of the following symptoms: [1] opsoclonus, [2] myoclonus and/or ataxia, [3] behavioural change and/or sleep disturbance and [4] neuroblastoma.
Age-matched children with pilocytic astrocytoma, diagnosed and treated at the Sophia Children*s Hospital will be included.

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded from participation in this study:
- Insufficient command of the Dutch language (spoken and/or written)
- Age above 12 years
Children with pilocytic astrocytoma will be excluded from participation, when they were treated with radiotherapy.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The study will have multiple endpoints:<br /><br>* Computer-assisted assessments:<br /><br>- Eye tracking: smooth pursuit and saccades;<br /><br>- Balance plate: scatter in center-of-gravity;</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* Clinical endpoints<br /><br>- OMS rating scale score;<br /><br>- SARA-score.<br /><br>* Computer-assisted assessments:<br /><br>- Score *Shelby*s Quest*.<br /><br>* Questionnaires; </p><br>