NCT00849914CompletedNot Applicable
Expression Levels of microRNA Processing Enzymes Dicer and Drosha in Epithelial Skin Cancer
Ruhr University of Bochum1 site in 1 country28 target enrollmentStarted: July 2008Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 28
- Locations
- 1
Study Overview
Brief Summary
MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation. miRNAs bind to their target messenger RNAs (mRNAs), leading to cleavage or suppression of target mRNA translation based on the degree of complementarity. miRNAs have recently been shown to play pivotal roles in diverse developmental and cellular processes and linked to a variety of skin diseases and cancers. In the present study the expression profiles for the two most important miRNA processing enzymes Dicer and Drosha of actinic keratoses, basal cell carcinoma and squamous cell carcinoma are compared to healthy skin tissue.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with actinic keratoses, squamous cell carcinoma or basal cell carcinoma of the skin
Exclusion Criteria
- •Patients under 18 years of age
- •Patients with other forms of cancer in previous medical history
Investigators
Michael Sand
Dr.
Ruhr University of Bochum
Study Sites (1)
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