Effect of Glutamine on Reducing Myocardial Damage
Phase 3
- Conditions
- Acute coronary syndrome.Acute coronary thrombosis not resulting in myocardial infarctionI24.0
- Registration Number
- IRCT20151109024975N10
- Lead Sponsor
- Sari University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 106
Inclusion Criteria
Age over 18 years
Candidate for open heart surgery
Preoperative sinus rhythm
Normal function of liver, renal system, pulmonary system and thyroid
Exclusion Criteria
Emergency patients
Serious water and electrolyte disorders
Unwillingness to co-operate with the patient
History of chronic lung, liver, kidney and thyroid diseases and heart failure
Age over 80 years
Pregnant and lactating women
Patients who are hypersensitive to glutamine or who are banned in any way by their administration of glutamine
Total Bilirubin more than 10 mg / dL
Creatinine clearance less than 30 ml / min
Absolute Absence of Intestinal Feeding
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Myocardial injury after open heart surgery. Timepoint: The day before the surgery (before the intervention) and the first and second days after surgery. Method of measurement: SOFA score.
- Secondary Outcome Measures
Name Time Method Duration of admission to ICU. Timepoint: Duration of admission. Method of measurement: Patients follow up.;Duration of hospitalization. Timepoint: Duration of admission. Method of measurement: Patients follow up.;Mortality. Timepoint: Duration of admission. Method of measurement: Patients follow up.