The effect of multi-day continuous theta-burst stimulation on symptoms of cervical dystonia

Not Applicable

Recruiting

Conditions: Cervical dystonia
Neurological - Other neurological disorders
Musculoskeletal - Other muscular and skeletal disorders

Registration Number: ACTRN12621000417886

Lead Sponsor: Deakin University - Australian Government Research Training Program Scholarship

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 20

Inclusion Criteria

To be included in the study participants must be cervical dystonia patients aged 18 to 85, diagnosed by a physician with cervical dystonia 12 or more months ago. Participants must have had a subjective response to botulinum toxin treatment at some point, with their last botulinum toxin injection 2 or more months ago.

Exclusion Criteria

Severe head tremor, trauma to head or neck < 12 months prior to onset of dystonia, acquired dystonia (i.e., dystonia as a result of a traumatic brain injury, drug-induced, or as a result of another neurological condition), or pronounced head or neck tremor when lying down with neck supported.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes to average Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) score - clinical rating scale used to measure cervical dystonia symptoms.[ The TWSTRS will be measured both before and after the intervention in each session. ];A composite measure which will assess changes to the range of motion, angle, tilt and position of a participants head and neck in space, as measured through a custom-made neck kinematics device.[ The range of motion of a participants head and neck will be measured both before and after the intervention in each session. ]

Secondary Outcome Measures

Name	Time	Method
Finger-to-nose dysmetria test, which will be assessed whilst the participant is wearing the neck kinematics device, to measure proprioception.[ The dysmetria test will be conducted before and after the intervention in each session.];Changes to fMRI data, to determine if there are objective functional or structural changes in a participants brain, after the application of cTBS. The fMRI will be acquired whilst the participant is at rest (no task).[ The participant will undergo a scan before and after one block of the intervention..];Changes to DWI data (white matter microstructure within the brain), to determine if there are objective structural changes within a participants brain, after the application of cTBS.[ A scan will take place before and after one block of the intervention.]