Therapeutic effect of adjunctive continuous theta burst stimulation on orbitofrontal cortex in patients of obsessive compulsive disorder
Phase 3
- Conditions
- Health Condition 1: F422- Mixed obsessional thoughts and acts
- Registration Number
- CTRI/2023/09/057994
- Lead Sponsor
- Central Institute of Psychiatry
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Diagnosis of Obsessive-Compulsive Disorder using Diagnostic Criteria for Research (DCR) of ICD 11 DCR supplemented with ICD 11 for Mortality and Morbidity Statistics (February 2022 edition)
2. Y-BOCS score of 15 or above
3. Age between 18-60 years of either sex
4. Right-handed
5. Patients giving written informed consent
6. Patient should be on antiobsessive medication for at least 4 weeks
Exclusion Criteria
1. Co-morbid severe depression as measured by a HAM-D score of 23 or more
2. Patients with co-morbid neurological or any other psychiatric disorder
3. History of epilepsy, significant head injury or any neurosurgical procedure.
4. Patient with presence of pacemaker or other electronic implant, metal or magnetic objects in the brain.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction in Y-BOCS score after application of cTBSTimepoint: Reduction in Y-BOCS score as assessed at baseline, at 2 weeks and 6 weeks
- Secondary Outcome Measures
Name Time Method Changes in the amplitude & latency of the ERN component of ERP on GO/NO-GO taskTimepoint: Changes in the amplitude & latency of the ERN component of ERP on GO/NO-GO task will be assessed at baseline & 2 weeks