Evaluating the effectiveness of Theta Burst Stimulation (TBS) as a treatment for Posttraumatic Stress Disorder (PTSD) in an Australian Veteran Population – a pilot study

Not Applicable

Recruiting

• Conditions: Posttraumatic Stress Disorder (PTSD); Mental Health - Anxiety

• Registration Number: ACTRN12616001023448
• Lead Sponsor: Professor David Forbes

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-08-02
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Potential participants will be included if they:
- Are a veteran (ex-serving member of the Australian Defence Force)
- Have a DSM 5 diagnosis of PTSD as assessed by the research team using the Clinician Administered PTSD Scale (CAPS)
- Have had no increase or initiation of new psychoactive therapy or medication intended to treat PTSD in the four weeks prior to screening.

Exclusion Criteria

Potential participants will be excluded if they:
- Report an unstable medical condition, implanted devices such as pacemaker, medication pumps or electrodes in the heart, neurological disorder or any history of a seizure disorder or that they are currently pregnant or lactating; or
- Report a level or pattern of substance or alcohol use outside that recommended for TMS
- Are currently experiencing a severe Major Depressive Episode (as determined by the HAMD)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinician Administered PTSD Scale (CAPS) [Baseline, at the conclusion of treatment and 3 month follow up]

Secondary Outcome Measures

Name	Time	Method
Working memory and processing speed subtests on the Wechsler Adult Intelligence Scale 4th edition (Digit span, Letter Number Sequencing, Coding and Symbol Search) and Cogstate Brief Battery[Baseline, at the conclusion of treatment and 3 month follow up];Hamilton Depression Rating Scale (HAMD)[Baseline, at the conclusion of treatment and at 3 month follow up];Emotional Regulation Questionnaire (ERQ9)[Baseline, at the conclusion of treatment and 3 month follow up];The Dimensions of Anger Scale - 5 (DAR-5) [Baseline, at the conclusion of treatment and 3 month follow up];Trail Making Test A & B (TMT) which measures information processing and complex attention [Baseline, at the conclusion of treatment and 3 months post treatment follow up]