Resistance Training to Optimize Health in Pre-frail Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Attendance rate
研究概览
简要总结
Exercise programs, particularly resistance training programs using weights or resistance bands, can help improve or maintain mobility and function in older adults, preserve independent living, and improve quality of life. This study will examine the safety and feasibility of a novel, higher intensity resistance training program in older adults, and compare the effects with standard care, lower intensity training. It is anticipated that both programs will be safe and feasible, but higher-intensity training will lead to greater improvements in quality of life, mobility and strength, which are part of the physical phenotype definition of frailty and markers of mobility disability.
详细描述
It is critically important to identify effective strategies to reduce the risk and impact of mobility disability and frailty in older adults. Exercise, particularly resistance training (RT), has the potential to influence a person's ability to navigate around their environment and impact the components of the frailty phenotype which include weakness, physical inactivity, and slowness. Higher training intensities have been used with athletes and younger adults to achieve greater gains in strength, but the feasibility and effectiveness is less established in older persons who exhibit preclinical disability, or are at-risk for mobility decline where conservative protocols are typically employed. Higher intensity RT may be an innovative and effective strategy in preclinical disability pre-frailty to reduce the risk and impact of future frailty and mobility decline.
This study aims to examine: 1) the safety and feasibility of a 12-week higher intensity RT protocol in community dwelling older adults at risk for mobility disability, and 2) the effects of this protocol on walking, balance, muscle strength, quality of life compared to lower intensity RT
It is hypothesized that the higher intensity RT: 1) is safe and feasible for at-risk community-dwelling older adults, 2) more effective in improving walking, balance, muscle strength, and quality of life than lower intensity RT
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •self-reported mobility limitations
- •living in the community
- •not currently engaged in regular resistance training
- •able to follow instructions
排除标准
- •contraindications for intensive resistance training (e.g. recent cardiovascular event, fracture within the past 12 months)
- •musculoskeletal injuries for which intervention participants are receiving concomitant rehabilitation treatments
研究组 & 干预措施
Higher Intensity Resistance Training
Participants will take part in a 12-week higher-intensity resistance training protocol.
干预措施: Higher Intensity Resistance Training (Behavioral)
Lower Intensity Resistance Training
Participants will take part in a 12-week lower-intensity resistance training protocol that will serve as the active comparator.
干预措施: Lower Intensity Resistance Training (Behavioral)
结局指标
主要结局
Attendance rate
时间窗: Entire duration of the intervention (12 weeks)
Attrition rate
时间窗: Entire duration of the intervention (12 weeks)
Occurrence of adverse events
时间窗: Entire duration of the intervention (12 weeks)
次要结局
- EQ-5D-5L(0, 12, 20 weeks)
- Short Physical Performance Battery(0, 12, 20 weeks)
- Activities-Specific Balance Confidence scale(0, 12, 20 weeks)
- Healthcare Utilization Questionnaires(0, 12, 20 weeks)
- Timed Up and Go Test(0, 12, 20 weeks)
- Berg Balance Scale(0, 12, 20 weeks)
- Muscle strength(0, 12, 20 weeks)
- Peripheral Quantitative Computed Tomography analysis of muscle and bone quality(0, 12, 20 weeks)
- Short Form-36(0, 12, 20 weeks)
- Caregiver Burden Interview Short Form(0, 12, 20 weeks)