Effects of Ambient Air Pollution Exposure in Patients With Stable Angina Pectoris During Normal Daily Activities
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 1
- 试验地点
- 2
- 主要终点
- Symptoms of angina pectoris - assessed by symptom diary and reliever medication usage
研究概览
简要总结
The purpose of this study is to identify whether exposure to ambient levels of air pollution during normal daily activities has a functional impact on patients with coronary heart disease
详细描述
Exposure to air pollution has been shown in epidemiological studies to be closely linked to cardiovascular morbidity and mortality. The exact components of air pollution that underlie the cardiovascular effects are not yet known, but combustion-derived particulate matter is suspected to be the major cause. In controlled exposure studies, we have recently demonstrated that exposure to diesel exhaust causes increased myocardial ischaemia with exercise in patients with asymptomatic coronary artery disease. The mechanism behind this effect is not yet understood, but we have shown that diesel exhaust exposure causes an acute impairment of two important and highly relevant aspects of vascular tone: vasomotor tone and endogenous fibrinolysis. In this study we propose to investigate the effects of exposure to ambient levels of air pollution on patients with stable, symptomatic angina pectoris, during their daily lives.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Documented coronary artery disease
- •Symptoms of stable angina pectoris
- •Positive BRUCE exercise stress test between 3 and 13 minutes
排除标准
- •History of arrhythmia
- •Severe 3 vessel coronary disease or left main stem stenosis that has not been revascularised
- •Resting conduction abnormality
- •Digoxin therapy
- •Uncontrolled hypertension
- •Renal or hepatic failure
- •Unstable symptoms or acute coronary syndrome within 3 months
结局指标
主要结局
Symptoms of angina pectoris - assessed by symptom diary and reliever medication usage
时间窗: Throughout study period
次要结局
- Exercise capacity - determined by standard BRUCE exercise stress testing(Immediately after study period)
- Time to 1mm ST segment depression during standard BRUCE exercise stress testing(At the end of the study period)
- Ambulatory blood pressure(Throughout study period)
- Myocardial ischaemic burden - assessed using 12-lead continuous Holter ECG monitoring(Throughout study period)
- Total exercise capacity - measured using GPS tracking of activity completed(Throughout study period)
- Biochemical evidence of myocardial ischaemia - highly sensitive troponin, ischaemically modified albumin and fatty acid binding protein(Before and after study period)
研究者
Jeremy Langrish
Clinical Lecturer and Specialty Registrar in Cardiology
University of Edinburgh