Positive End-expiratory Pressure and Alveolar Recruitment for One Lung Ventilation

Not Applicable

Completed

• Conditions: One Lung Ventilation
• Interventions: Other: PEEP

• Registration Number: NCT01652612
• Lead Sponsor: Yonsei University

Brief Summary

Hypoxia frequently develops during one lung ventilation in the supine position.The objective of this article is to study the impact of preemptive alveolar recruitment and subsequent positive end expiratory pressure on arterial oxygenation and lung mechanics during one lung ventilation in the supine position in patients undergoing thoracic surgery .

Detailed Description

outcome measures: respiratory parameters (Paw, Ppla, Compliance, Vd/Vt)and oxygenation parameters (PaO2, shunt fraction, Pa-AO2)

Study Timeline

• Study Start: 2011-08
• Study First Submitted: 2011-12-20
• Study First Submitted QC: 2012-07-25
• Study First Posted: 2012-07-30
• Primary Completion: 2013-02
• Study Completion: 2013-02
• Status Verified: 2013-07
• Last Update Submitted: 2013-07-03
• Last Update Posted: 2013-07-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 99

Inclusion Criteria

• ASA I-II
• age: 20-75 years

Exclusion Criteria

• moderate to severe impaired respiratory function,
• heart failure,
• patients' refusal

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
OLV strategy: PEEP	PEEP	1. apply 8 cm H2O positive end expiratory pressure during one lung ventilation and until the end of surgery
OLV strategy: PEEP followed by AR	PEEP	1. alveolar recruitment strategy before one lung ventilation 2. 8 cmH2O positive end expiratory pressure during one lung ventilation and until the end of surgery

Primary Outcome Measures

Name	Time	Method
PaO2, number of patients with hypoxia (PaO2< 90mmHg)	participants will be followed for the duration of anesthesia, an expected average of 3 hours	blood samplings after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV

Secondary Outcome Measures

Name	Time	Method
intrapulmonary shunt	participants will be followed for the duration of anesthesia, an expected average of 3 hours	blood sampling after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV

Trial Locations

Locations (1)

Yong Seon Choi; 🇰🇷 Seoul, Korea, Republic of