Efficacy of Sodium bicarbonate buffered lidocaine anaesthetic solutio

Not Applicable

• Conditions: Anaesthesia; Oral Health

• Registration Number: PACTR202311916835461
• Lead Sponsor: myself

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-10-23
• Last Update Posted: 4 March 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 220

Inclusion Criteria

1.Patients requiring intra-alveolar extraction of mandibular first and/or second molar.
2.Patients between the ages of 18-60years
3.Patients with American Society of Anesthesiologists (ASA) I and II health status at the time of treatment.

Exclusion Criteria

1.Patients with known underlying systemic diseases such as bleeding dyscrasia and immunosuppression [e.g. uncontrolled diabetes mellitus, clotting disorder, hyperthyroidism, arteriosclerosis, cardiac insufficiency, other cardiovascular disorders, Auto-immunodeficiency Syndrome (AIDS)].
2.Patients with allergy or hypersensitivity to any of the constituents of the anaesthetic solution in the surgical protocol.
3.Patients on anticoagulants
4. Patients taking any medications that would alter pain perception (opioids, synthetic cannabinoids, hallucinogens, antidepressants, anticonvulsants, methamphetamine, cocaine, benzodiazepines, 3,4-Methylenedioxymethamphetamine, Serotonin-Norepinephrine Re-uptake Inhibitors)
5.Patients who are current smokers and chronic alcoholics for more than two months
6.Patients with cognitive or physical impairment
7.Pregnant women and/or breastfeeding mothers
8.Inability to give informed consent
9.Teeth with abscess at the time of extraction

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Efficacy in term of failure to achieve anaesthesia

Secondary Outcome Measures

Name	Time	Method
degree of pain on injection;Anaesthetic onset of action;Comfort of the extraction procedure