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Clinical Trials/ISRCTN65605485
ISRCTN65605485Completed未知

Effects of short-term energy restriction on liver lipid content, metabolism and inflammatory status in severely obese adults

niversity of Nottingham (UK)0 sites100 target enrollmentStarted: May 17, 2012Last updated:
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Trial Snapshot

Phase
未知
Status
Completed
Sponsor
Enrollment
100
Study OverviewEligibility CriteriaInvestigatorsRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

2017 results in: https://www.ncbi.nlm.nih.gov/pubmed/28230324

Study Design

Study Type
Interventional

Eligibility Criteria

Sex
All

Inclusion Criteria

  • •1. Patients accepted for weight loss surgery at Derby Hospitals NHS Foundation Trust
  • •2. Male and female participants
  • •3. Lower age limit = 18 years, no upper age limit

Exclusion Criteria

  • •1. Secondary NAFLD
  • •2. Diabetes mellitus treated by insulin, GLP1 or pioglitazone
  • •3. Excess alcohol intake (exceeding national recommendations)
  • •4. Patients receiving anti-inflammatory medication
  • •5. Pregnancy and lactation
  • •6. Any other condition judged by the investigative team to be clinically significant
  • •Exclusions recommended by LighterLife (meal replacement plan):
  • •7.1. Some cardiac conditions (including heart failure, arrhythmias, valve disease, requiring treatment)
  • •7.2. Some cerebrovascular conditions. (Patients who have suffered cerebrovascular disease may participate if the following conditions are met; more than six months has passed and the patient?s condition is stable)
  • •7.3. Schizophrenia, delusional and bipolar disorder, psychosis
  • •7.4. Epilepsy or history of seizure
  • •7.5. Kidney or liver disease (severe)
  • •7.6. Total lactose intolerance
  • •7.7. Type 1 diabetes
  • •7.8. Anorexia or bulimia or other eating disorder undergoing or awaiting treatment.
  • •7.9. Porphyria
  • •7.10. Taking prescribed anticoagulants, digoxin, lithium or monoamine oxidase inhibitors (MAOIs)
  • •7.11. Unstable angina
  • •7.12. Major depressive disorder

Investigators

Sponsor
niversity of Nottingham (UK)

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