Effect of 24 h Severe Energy Restriction on Appetite Regulation and Ad-libitum Energy Intake in Lean Males and Females
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 主要终点
- Ad-libitum energy intake
研究概览
简要总结
Long term maintenance of weight loss is generally poor, which is at least partly due to increased feelings of hunger associated with restricting what can be eaten. Intermittent severe energy restriction is a novel dietary strategy that requires individuals to consume a very-low energy diet for 1-4 days per week, allowing normal feeding patterns to be adopted on the other days in the week. However, the effect of a consuming a very-low energy diet on appetite regulation, which might represent a key marker of long-term adherence to dieting, has not been determined. This study aimed to assess the effects of severely restricting energy intake for 24 h on markers of appetite regulation, energy balance and metabolism compared to an adequate energy trial.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •non-smoker, not currently dieting, weight stable for >6 months (self-reported), no known history of cardiovascular or renal disease.
排除标准
- •food allergies, dislike or intolerance of study foods and drinks, irregular eating patterns, use of medication that could influence hormone concentrations, excessive alcohol consumption (>4 units/day), intensive training schedule (>10 h/week)
结局指标
主要结局
Ad-libitum energy intake
时间窗: 48 hours
Measured at laboratory-based meals and weight food records
Plasma acylated Ghrelin
时间窗: 24 hours
Measured using ELISA from venous blood samples
Plasma active glugagon-like peptide 1
时间窗: 24 hours
Measured using ELISA from venous blood samples
Subjective appetite
时间窗: 48 hours
Measured using visual analogue scales
次要结局
- Plasma insulin(24 hours)
- Plasma glucose(24 hours)
- Fat oxidation(24 hours)
- carbohydrate oxidation(24 hors)
- Plasma Non-esterified Fatty acids(24 hours)
- Energy expenditure(24 hours)
研究者
Lewis James
Lecturer in Nutrition
Loughborough University