The effect of ultraviolet radiation on the skin manifestations of patients with dermatomyositis
Completed
- Conditions
- DermatomyositisSkin and Connective Tissue Diseases
- Registration Number
- ISRCTN35411849
- Lead Sponsor
- niversity Medical Centre Utrecht (UMCU) (Netherlands)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
1. Patients with dermatomyositis (DM) that have been diagnosed according to international accepted guidelines (1 - 3)
2. The medication that is used by the patients specifically for DM or other related symptoms will be continued during phototesting
3. The patients should not use corticosteroid creams or sunscreens during phototesting
4. Patients with DM are invited to participate in this study and are included after signed informed consent is obtained
Exclusion Criteria
Any malignancy for which the patient is treated with cytostatic drugs and/or radiotherapy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Determine the initial cutaneous response after UVB provocation of the skin. Specifically we will determine the trafficking of Langerhans cell, leucocytes and lymphocytes and the expression of MMP in skin lesions and compare these with healthy controls, patients with lupus erythematosus and patients with polymorphic light eruption, for which the results have already been obtained.
- Secondary Outcome Measures
Name Time Method ot provided at time of registration