The effect of ultraviolet radiation on the skin manifestations of patients with dermatomyositis.
Completed
- Conditions
- Dermatomyositis
- Registration Number
- NL-OMON22361
- Lead Sponsor
- Dept of Dermatology/AllergologyUniversity Medical CentreHeidelberglaan 100, G02.1243584CX UtrechtNetherlands
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
1. Patients with DM that have been diagnosed according to international accepted guidelines (1-3);
2. The medication that is used by the patients specifically for DM or other related symptoms will be continued during phototesting;
Exclusion Criteria
Any malignancy for which the patient is treated with cytostatic drugs and/or radiotherapy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method In summary, we will determine the initial cutaneous response after UVB provocation of the skin. Specifically we will determine the trafficking of Langerhans cell, leucocytes and lymphocytes and the expression of MMP in skin lesions and compare these with healthy controls, patients with lupus erythematosus and patients with polymorphic light eruption, for which the results have already been obtained.
- Secondary Outcome Measures
Name Time Method