Study to compare the effect of fentanyl and dexmedetomidine when added to 0.5% Bupivacaine in brachial plexus block for upper limb surgeries

Not yet recruiting

• Conditions: Open wound of elbow, (2) ICD-10 Condition: S529||Unspecified fracture of forearm, (3) ICD-10 Condition: S629||Unspecified fracture of wrist andhand,

• Registration Number: CTRI/2022/11/047044
• Lead Sponsor: Madiha Mehmood Ansari

Brief Summary

Variousclinical trials have found that administration of dexmedetomidine and fentanylwith local anaesthetics in neuraxial and peripheral nerve blocks prolonged theduration of sensory and motor blockade.

However, there arelimited data available on comparing of dexmedetomidine and fentanyl as adjuvantto Bupivacaine in brachial plexus block. Considering the low side effect andexcellent postoperative analgesic efficacy of two drugs, it is essential tocarry out a comparative evaluation of two drugs for their use with bupivacaine asadjuvant in patients undergoing upper limb surgeries which requiresupraclavicular brachial plexus block. To compare whether adding dexmedetomidineand fentanyl to bupivacaine for supraclavicular brachial plexus block wouldaffect the sensory and motor blocks and duration of analgesia.  The present work has been undertaken to studyand compare the effect provided by dexmedetomidine and fentanyl as adjuvants tobupivacaine in supraclavicular block.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-02-11
• Study Start: 2022-10-11

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Age18 years.
• ASA grade 1 and 2.
• Scheduled for elective upper limb surgeries under supraclavicular brachial plexus block.

Exclusion Criteria

• Lack of patient’s consent.
• Age <18yrs and >60yrs.- ASA grade 3 and more.
• History of serious pulmonary disease, ischemic heart disease, renal/hepaticdysfunction, coronary artery, or cervical spine disease and patients with abnormal coagulation profile.
• Patient with h/o opioid abuse.
• Patients with hypersensitivity to any of the drugs used.
• Pregnant and lactating mothers.
• Failure of Block.
• Restricted neck movement.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the efficacy of 0.5% Bupivacaine with dexmedetomidine, 0.5% Bupivacaine with fentanyl and 0.5% Bupivacaine innerve stimulator guided supraclavicular brachial plexus block.	First 24 hours at 5 mins, 10 mins, 15 mins, 30 mins, 1 hour, 2 hour, 4 hours, 6 hours, 12 hours and 24 hours

Secondary Outcome Measures

Name	Time	Method
To compare side effects of 0.5% Bupivacaine with dexmedetomidine, 0.5% Bupivacaine with fentanyl and 0.5% Bupivacaine innerve stimulator guided supraclavicular brachial plexus block.	First 24 hours at 5 mins, 10 mins, 15 mins, 30 mins, 1 hour, 2 hour, 4 hours, 6 hours, 12 hours and 24 hours

Trial Locations

Locations (1)

People’s College of Medical Science and Research Center; 🇮🇳 Bhopal, MADHYA PRADESH, India

People’s College of Medical Science and Research Center

🇮🇳Bhopal, MADHYA PRADESH, India

Madiha Mehmood Ansari

Principal investigator

8839880699

madihaansari93@gmail.com