The Proposed Study Aims to Investigate the Efficacy of Quercetin as an Adjunctive to Mechanical Debridement in Treatment of Periodontitis

Phase 2

Active, not recruiting

• Conditions: Periodontal Pocket
• Interventions: Drug: NSP and chitosan nanoparticles gel loaded by quercetin; Drug: NSP and chitosan nanoparticles gel; Procedure: scaling and root planning

• Registration Number: NCT06982248
• Lead Sponsor: Mansoura University

Brief Summary

the proposed study aims to investigate the effect of Quercetin in treatment of periodontitis patients

Detailed Description

the proposed study aims to investigate the effect of Quercetin in treatment of periodontitis patients not having systemic diseases.the 2ry aim of study to estimate the neacular factor kabba B level in gingival crevicular fluids.

Study Timeline

• Study Start: 2024-08-15
• Study First Submitted: 2024-12-11
• Primary Completion: 2025-02-01
• Status Verified: 2025-05
• Study First Submitted QC: 2025-05-19
• Last Update Submitted: 2025-05-19
• Study First Posted: 2025-05-21
• Last Update Posted: 2025-05-21
• Study Completion: 2025-06-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients of both sexes with an age ranging between 25 and 55 years will be included in the study. Patients diagnosed as having periodontitis based on clinical and radiographic examinations will be included

Exclusion Criteria

• Insulin dependent diabetes
• Thyroid disease
• Patients with sensitivity to the medication used in the study
• patients with a history of antibiotic use or anti-inflammatory drugs during the previous 3 months prior to the study will be excluded from the study.
• Additionally, patients with systemic diseases, smokers, pregnant and lactating patients, and patients not compliant with oral hygiene procedures will also be excluded

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Group 1: Periodontitis patients treated by NSPT and chitosan nanoparticles gel loaded by quercetin	NSP and chitosan nanoparticles gel loaded by quercetin	selected patients receive SRP and chitosan nanoparticles gel loaded by quercetin
Group 2: Periodontitis patients treated by NSPT and chitosan nanoparticles gel.	NSP and chitosan nanoparticles gel	selected patients receive SRP and chitosan nanoparticles gel
Group 3: Periodontitis patients treated by NSPT only	scaling and root planning	NSPT

Primary Outcome Measures

Name	Time	Method
assessment clinical attachment level by UNC 15 periodontal probe	12 weeks

Secondary Outcome Measures

Name	Time	Method
assessment of the gingival crevicular levels of NF-κB by Elisa kit	12 weeks

Trial Locations

Locations (1)

Faculty of Dentistry, Mansoura University; 🇪🇬 Aga, Egypt