Phenylephrine and Pulse Pressure Variability

Phase 1

Completed

• Conditions: Intraoperative Hypotension

• Registration Number: NCT05011357
• Lead Sponsor: University of Texas Southwestern Medical Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-8-11
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria:<br><br> - 18 to 45 years of age<br><br> - Non-obese (Body Mass Index less than 30 kg/m2)<br><br> - Baseline systolic blood pressure between 80-140 mmHg<br><br> - Baseline diastolic blood pressure <90 mmHg<br><br>Exclusion Criteria:<br><br> - Participants who have cardiac, vascular, respiratory, neurological and/or metabolic<br> illness<br><br> - Current or previous use of anti-hypertensive medications<br><br> - Any known history of renal or hepatic insufficiency/disease<br><br> - Pregnancy (verified by negative urine test on the experimental days) or<br> breast-feeding<br><br> - Current smokers, as well as individuals who regularly smoked within the past 3 years<br><br> - Sulfite allergy, as this is a contraindication to intravenous phenylephrine<br><br> - Serious mental illness including claustrophobia<br><br> - History of use of recreational drugs including cocaine or amphetamines<br><br> - Peripheral vascular disease<br><br> - Subject on anticoagulant treatment<br><br> - Subjects with a baseline systolic blood pressure <80 mmHg

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pulse Pressure Variability