Light Therapy in Parkinson's Disease

Not Applicable

Completed

• Conditions: Parkinson's Disease
• Interventions: Device: Placebo light therapy

• Registration Number: NCT02072642
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Parkinson's disease, a degenerative disorder of the dopaminergic system, combines motor symptoms but also non-motor, such as depression, sleep disorders and circadian rhythms and impaired cognitive functions. Difficulties in balancing the dopaminergic treatment of these patients emphasizes the need to find effective adjuvant therapies. Light therapy (LT) represents one such innovative therapeutic approach. Although light has an obvious to visual pathways within the brain, today it is known to additionally exert non-visual effects throughout the body. Recently our team has shown that non-visual, non-circadian light plays a major role in the regulation of sleep, as well as cognitive brain function in general. The retina, the primary conduit for the transmission of light information is weakened or thinned in Parkinson's patients. The dopamine system is known to enhance the processing of light information and intraocular injection of L-dopa in animal models of Parkinson's disease, can reverse associated motor symptoms. This allows for the possibility that LT would strengthen the dopaminergic tone in the central nervous system. However, to this date its effectiveness for alleviating Parkinson's symptoms has only been suggested by two studies, both poorly controlled. Thus, through the convergence of basic and clinical data, a study examining the effect of LT directly in people Parkinson's disease symptoms, whilst controlling for the effects on sleep, circadian system, mood, and cognitive functioning, is of extreme importance. With this information our hope is to determine if these polymorphisms allow for a predictive model of response to LT treatment.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-04
• Study First Submitted: 2014-02-24
• Study First Submitted QC: 2014-02-25
• Study First Posted: 2014-02-26
• Primary Completion: 2023-03-10
• Study Completion: 2023-05
• Status Verified: 2023-08
• Last Update Submitted: 2023-08-10
• Last Update Posted: 2023-08-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

• Idiopathic Parkison's Disease, low or moderately severe
• Hoehn&Yahr <4
• 4 to < 15 years of evolution·
• Between 45-75 years old
• Absence of dementia : MMSE > 23·
• No severe depression
• Stable medication levels during the 5 weeks before inclusion

Exclusion Criteria

• Secondary or severe Parkinson's disease
• Ocular pathologies (i.e. retinopathy)
• Photosensitive medication
• Antidepressant treatment·
• Major depression syndrome
• MMSE < 23
• Circadian rhythm problems
• Sleep apnea syndrome
• Manifested or acute psychiatric comorbidities
• Pregnant women

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo light therapy (70 lux)	Placebo light therapy	Placebo light therapy

Primary Outcome Measures

Name	Time	Method
Global score :Unified Parkinson's Disease Rating Scale (UPDRS) I II III	5 weeks

Trial Locations

Locations (1)

University Hospital, Strasbourg, france; 🇫🇷 Strasbourg, France