Mycoprotein Consumption and Glucose Absorption

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: Mycoprotein Ingestion

• Registration Number: NCT04084639
• Lead Sponsor: University of Exeter

Brief Summary

Previous research has demonstrated that the food found in Quorn 'Mycoprotein' can lower the blood glucose response to a meal, which may be an important finding for the management of type 2 diabetes. However, it has never been investigated how this lower response occurs, and whether there is dose-dependent response with mycoprotein. The present study will include 12 healthy young adults, who will visit the laboratory for 3 test days, with each day lasting 9 hours. On each visit, separated by a washout period of at least 2 weeks, participants will ingest either a control drink with no mycoprotein, a drink containing 20g mycoprotein or a drink containing 40g mycoprotein. By intravenously infusing labelled glucose during each visit in combination with repeated blood sampling, investigators will determine if the lower blood glucose after mycoprotein ingestion is due to reduced glucose absorption from the gut or increased uptake into body tissues.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-08-28
• Study First Submitted: 2019-09-06
• Study First Submitted QC: 2019-09-06
• Study First Posted: 2019-09-10
• Primary Completion: 2019-10-16
• Study Completion: 2019-10-16
• Status Verified: 2019-11
• Last Update Submitted: 2019-11-06
• Last Update Posted: 2019-11-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Male and female
• 18-35 years of age
• Consumption of sufficient amounts of carbohydrate in the diet
• Body mass index between 18.5 and 30

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Exclusion Criteria

• Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes), or other form of abnormal glucose metabolism (as this will affect outcome of the study).
• Any diagnosed cardiovascular disease
• Insufficient consumption of carbohydrate in the diet
• A personal or family history of epilepsy, seizures or schizophrenia
• Known pre-existing liver disease/condition
• Allergy or intolerance to milk

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Ingestion of Isocaloric Control Drink	Mycoprotein Ingestion	Milkshake containing 250ml full-fat milk, 50g glucose, 19g dried skim milk and 9g full-fat dried milk
Ingestion of 20g Mycoprotein Drink	Mycoprotein Ingestion	Milkshake containing 20g of mycoprotein, 250ml full-fat milk, 50g glucose and 11g lactose is given to participants in one dose
Ingestion of 40g Mycoprotein Drink	Mycoprotein Ingestion	Milkshake containing 40g of mycoprotein, 250ml full-fat milk, 50g glucose and 11g lactose is given to participants in one dose

Primary Outcome Measures

Name	Time	Method
Glucose absorption	6 hours following ingestion of drink	How glucose is absorbed following the ingestion of a mycoprotein drink compared to a placebo control measured using the infusion of stable isotopes

Secondary Outcome Measures

Name	Time	Method
Insulinaemic Response	6 hours following ingestion of drink	Measurement of insulin response following ingestion of drinks
Incretin Hormones	6 hours following ingestion of drink	Measurement of glucagon-like peptide-1(GLP-1) and gastric inhibitory polypeptide (GIP) in response to mycoprotein ingestion compared to placebo control
Production of Short-Chain Fatty Acids	6 hours following ingestion of drink	Measurement of plasma acetate production in response to mycoprotein ingestion
Glucose Kinetics	6 hours following ingestion of drink	Calculations using plasma deuterated glucose enrichment to determine rate of appearance of endogenous glucose, rate of disappearance of glucose and rate of appearance of exogenous glucose

Trial Locations

Locations (1)

University of Exeter; 🇬🇧 Exeter, United Kingdom