Quorn in Community Health Experiment

Not Applicable

Completed

• Conditions: Overweight and Obesity
• Interventions: Dietary Supplement: Meat/fish products; Dietary Supplement: Quorn Foods products

• Registration Number: NCT04773483
• Lead Sponsor: University of Exeter

Brief Summary

In overweight individuals (BMI \> 27.5 kg/m2), does daily consumption of mycoprotein containing Quorn Food products lower blood cholesterol compared with daily meat/fish consumption?

Detailed Description

Not available

Study Timeline

• Study Start: 2020-11-09
• Study First Submitted: 2021-02-22
• Study First Submitted QC: 2021-02-25
• Study First Posted: 2021-02-26
• Primary Completion: 2021-12-17
• Study Completion: 2021-12-17
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-21
• Last Update Posted: 2023-03-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 82

Inclusion Criteria

• 18-70 years old
• BMI >27.5 kg/m2
• Non allergic to penicillin/mycoprotein
• Moderate levels of physical activity or below (self-identified; NDNS servey)
• Omnivores
• Not currently using cholesterol lowering medication

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Exclusion Criteria

• <18 or >70 years old
• BMI <27.5 kg/m2
• Allergies to penicillin/mycoprotein
• Heavy exercisers (self idenfiied)
• Vegetarian/vegans
• Currently using cholesterol lowering medication

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Meat/fish products	Meat/fish products	-
Quorn Food products	Quorn Foods products	-

Primary Outcome Measures

Name	Time	Method
Postabsorptive blood cholesterol (free, total, LDL, HDL) concentrations	4 weeks	Test for intervention vs control differences in postabsorptive blood cholesterol levels (mMol) pre and post intervention

Secondary Outcome Measures

Name	Time	Method
Postprandial blood cholesterol concentration	3 hours	Test for intervention vs control differences in postprandial blood cholesterol levels (mMol) pre and post intervention
Fingerprick blood glucose concentration	4 weeks	Test for intervention vs control differences in blood glucose concentration (mMol) in postabsorptive and postprandial state
Satiety	4 weeks	Test for intervention vs control differences in satiety using a 10 centimetre 'Satiety Visual Analogue Scale' ratings, anchored by minimum to maximum response for a given aspect of satiety, where 0 cm is minimum and 10 cm is maximum
Hedonic visual analogue scale	4 weeks	Test for intervention vs control differences and changes in hedonic response using 10 cm 'Hedonic Visual Analogue Scale' ratings, anchored by minimum to maximum response for a given aspect of hedonic response, where 0 cm is minimum and 10 cm is maximum
Gastrointestinal side-effects	Once weekly, over 4 weeks	Test for intervention vs control differences in tolerance of diet
Fingerprick blood c-peptide	4 weeks	Test for intervention vs control differences in C-peptide concentration (ng/ml) in postabsorptive and postprandial state
Fingerprick blood triglyceride concentration	4 weeks	Test for intervention vs control differences in blood triglyceride concentration (mMol) in postabsorptive and postprandial state

Trial Locations

Locations (1)

University of Exeter; 🇬🇧 Exeter, Devon, United Kingdom