Chronic Mycoprotein Consumption and Nucleotide Content in Metabolic Health

Not Applicable

Completed

• Conditions: Healthy

• Registration Number: NCT02984358
• Lead Sponsor: University of Exeter

Brief Summary

Compare chronic (one week) of a 'normal' meat diet with one week of mycoprotein consumption, with or without a reduced nucleotide content, on markers of metabolic health, such as uric acid concentrations, blood glucose control and blood lipid profiles.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-12-02
• Study First Submitted QC: 2016-12-02
• Study First Posted: 2016-12-06
• Study Start: 2017-01
• Primary Completion: 2017-12
• Study Completion: 2017-12
• Status Verified: 2018-06
• Last Update Submitted: 2018-06-13
• Last Update Posted: 2018-06-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• BMI between 18 and 30

Exclusion Criteria

• On medication (except contraception)
• Smokers
• Diagnosed with any metabolic or cardiovascular conditions
• BMI < 18 or > 30
• Dietary restrictions (vegetarians/vegans, etc.)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Serum uric acid concentrations	Measured at baseline; days 2, 4 and 6 of the intervention; and after the 1 week intervention (day 8)

Secondary Outcome Measures

Name	Time	Method
Glycaemia and serum insulin - insulin sensitivity (oral glucose tolerance test)	Measured at baseline and after 1 week intervention (day 8)
IL-6	Measured at baseline and after 1 week intervention (day 8)
24 h blood glucose homeostasis - measured using a Dexcom CGMS	Measured 5 days at baseline (habitual data) and 5 days during the intervention (days 3 - 7)
Metabolomics (using Nuclear Magnetic Resonance - NMR)	Measured at baseline; days 2, 4 and 6 of the intervention; and after the 1 week intervention (day 8)