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Chronic Mycoprotein Consumption and Nucleotide Content in Metabolic Health

Not Applicable
Completed
Conditions
Healthy
Interventions
Other: Animal protein based diet
Other: Low-nucleotide mycoprotein based diet
Other: High-nucleotide mycoprotein based diet
Registration Number
NCT02984358
Lead Sponsor
University of Exeter
Brief Summary

Compare chronic (one week) of a 'normal' meat diet with one week of mycoprotein consumption, with or without a reduced nucleotide content, on markers of metabolic health, such as uric acid concentrations, blood glucose control and blood lipid profiles.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
30
Inclusion Criteria
  • BMI between 18 and 30
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Exclusion Criteria
  • On medication (except contraception)
  • Smokers
  • Diagnosed with any metabolic or cardiovascular conditions
  • BMI < 18 or > 30
  • Dietary restrictions (vegetarians/vegans, etc.)
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Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Animal protein based dietAnimal protein based dietSeven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by animal products (meat and fish).
Low-nucleotide mycoprotein based dietLow-nucleotide mycoprotein based dietSeven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by nucleotide-depleted mycoprotein products (commercial Quorn products).
High-nucleotide mycoprotein based dietHigh-nucleotide mycoprotein based dietSeven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by nucleotide-rich mycoprotein products.
Primary Outcome Measures
NameTimeMethod
Serum uric acid concentrationsMeasured at baseline; days 2, 4 and 6 of the intervention; and after the 1 week intervention (day 8)
Secondary Outcome Measures
NameTimeMethod
Glycaemia and serum insulin - insulin sensitivity (oral glucose tolerance test)Measured at baseline and after 1 week intervention (day 8)
IL-6Measured at baseline and after 1 week intervention (day 8)
24 h blood glucose homeostasis - measured using a Dexcom CGMSMeasured 5 days at baseline (habitual data) and 5 days during the intervention (days 3 - 7)
Metabolomics (using Nuclear Magnetic Resonance - NMR)Measured at baseline; days 2, 4 and 6 of the intervention; and after the 1 week intervention (day 8)
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