Chronic Mycoprotein Consumption and Nucleotide Content in Metabolic Health
Not Applicable
Completed
- Conditions
- Healthy
- Interventions
- Other: Animal protein based dietOther: Low-nucleotide mycoprotein based dietOther: High-nucleotide mycoprotein based diet
- Registration Number
- NCT02984358
- Lead Sponsor
- University of Exeter
- Brief Summary
Compare chronic (one week) of a 'normal' meat diet with one week of mycoprotein consumption, with or without a reduced nucleotide content, on markers of metabolic health, such as uric acid concentrations, blood glucose control and blood lipid profiles.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- BMI between 18 and 30
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Exclusion Criteria
- On medication (except contraception)
- Smokers
- Diagnosed with any metabolic or cardiovascular conditions
- BMI < 18 or > 30
- Dietary restrictions (vegetarians/vegans, etc.)
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Animal protein based diet Animal protein based diet Seven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by animal products (meat and fish). Low-nucleotide mycoprotein based diet Low-nucleotide mycoprotein based diet Seven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by nucleotide-depleted mycoprotein products (commercial Quorn products). High-nucleotide mycoprotein based diet High-nucleotide mycoprotein based diet Seven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by nucleotide-rich mycoprotein products.
- Primary Outcome Measures
Name Time Method Serum uric acid concentrations Measured at baseline; days 2, 4 and 6 of the intervention; and after the 1 week intervention (day 8)
- Secondary Outcome Measures
Name Time Method Glycaemia and serum insulin - insulin sensitivity (oral glucose tolerance test) Measured at baseline and after 1 week intervention (day 8) IL-6 Measured at baseline and after 1 week intervention (day 8) 24 h blood glucose homeostasis - measured using a Dexcom CGMS Measured 5 days at baseline (habitual data) and 5 days during the intervention (days 3 - 7) Metabolomics (using Nuclear Magnetic Resonance - NMR) Measured at baseline; days 2, 4 and 6 of the intervention; and after the 1 week intervention (day 8)