RESPONSE TIMES IN VOLUNTEERS UNDERGOING PROPOFOL SEDATIO

Withdrawn

• Conditions: er wordt gekeken naar de reactiesnelheid na het geven van anesthesie; reponse time; sedation

• Registration Number: NL-OMON37153
• Lead Sponsor: anesthesiologie- onderzoeksbureau

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Age 50 * 72 years

Exclusion Criteria

-Volunteer refusal
- Significant cardiovascular or respiratory disease
- Vascular contra-indication for arterial line placement
-Loss of strength, motor skills or sensibility of the hands or arms

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Response times (squeezing the handset in response to vibration of a wrist<br /><br>device) will be recorded electronically (automatically) during increasing and<br /><br>decreasing sedation levels provided by a standardized effect-site targeted<br /><br>infusion algorithm administered by means of the RUGLOOP II system</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters will be recordings of routine physiological parameters<br /><br>(respiratory rate, oxygen-haemoglobin saturation, heart rate, blood pressure),<br /><br>propofol doses, propofol blood concentrations and computer estimates of blood<br /><br>and brain concentrations, and electronic recordings of the electroencephalogram<br /><br>(which will undergo offline analysis to calculate various processed EEG<br /><br>parameters and other parameters of depth of sedation). </p><br>