Effects of inhaled methoxyflurane (Penthrox) on psychomotor function in humans: a randomized placebo trial

Phase 4

Completed

• Conditions: Psychomotor function in humans who inhale methoxyflurane (Penthrox) as a mode of analgesia; Neurological - Studies of the normal brain and nervous system; Anaesthesiology - Pain management

• Registration Number: ACTRN12613000666729
• Lead Sponsor: Department of Gastroenterology and Hepatology, Royal Adelaide Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-06-19
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Able to give informed consent
Adequate understanding of use of the Penthrox inhaler

Exclusion Criteria

History of significant alcohol (>40gms/d for males, 20gms/d for females) or narcotic use.
Previous history of significant cardiac or respiratory illnesses (ie. ischaemic heart disease, chronic obstructive pulmonary disease).
Significantly underweight (<45kg)
Significant smoking history of more than 20 packs / year.
Previous history of gastrointestinal surgery (likely to increase difficulty of colonoscopy)
Renal impairment
Diabetes Mellitus
Previous possible allergy to the medication by the patient or a relative
Hypersensitivity to fluorinated agents
Previous head injury
Difficulty in following instructions (including language barrier)
Patients taking any potential nephrotoxic drugs (e.g. aminoglycosides)
Malignant hyperthermia

Study & Design

• Study Type: Interventional
• Study Design: Not specified