The effects of Glucagon-Like Peptide 1 on gastric emptying in healthy volunteers with normal or low blood glucose levels

Phase 2

Recruiting

• Conditions: Gastric emptying in the context of supraphysiologic Glucagon-Like Peptide-1 and hypoglycaemia; Metabolic and Endocrine - Other metabolic disorders; Oral and Gastrointestinal - Normal oral and gastrointestinal development and function

• Registration Number: ACTRN12611000973910
• Lead Sponsor: Dr Mark Plummer

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-09-12
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Healthy volunteer between 50 and 80 years of age.

Exclusion Criteria

- Unable to give informed consent;
- Vegetarian (as the study involves the consumption of a beef meal);
- Diabetes mellitus;
- Glycated haemoglobin (HbA1c) > 6.5%;
- Migraine or seizure disorder;
- Anormal ferritin or haemoglobin levels;
- Abnormal liver function test results;
- Previous gastrointestinal surgery;
- Receiving medication(s) that affect gastrointestinal motility or blood sugar;
- Body Mass Index >32 kg/m2;
- Smoking >10 cigarettes/day;
- Alcohol consumption >20 g/day;
- Previous exposure to radiation for research purposes in the preceding 12 months;
- Donation of blood in the preceding 3 months;
- Female volunteers of child bearing age who are pregnant, lactating or who have inadequate contraception.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gastric emptying.[Measured by radioisotopic gamma camera. This camera takes frames every 1 minute for the first 60 minutes and then every 3 minutes for the remaining 120 minutes. The recording begins at t = 0 (the time at which the meal and drink are consumed) and continues until t = 180.]