Novel Nutrition Solutions in Elderly at Risk of Sarcopenia: LC n-3 PUFA and Leucine Combinations
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 108
- 试验地点
- 1
- 主要终点
- Appendicular skeletal muscle mass
研究概览
简要总结
This study will examine the effect of leucine-enriched protein supplementation, alone and in combination with long chain n-3 polyunsaturated fatty acids (LC n-3 PUFA), on muscle mass and function in older adults at risk of sarcopenia.
The investigators hypothesize that LC n-3 PUFA supplementation will further enhance the efficacy of the leucine-enriched protein.
详细描述
The progressive loss of skeletal muscle mass and function with advancing age, termed sarcopenia, contributes substantially to disability, physical dependence, and mortality among older adults. Aging is associated with an attenuated muscle protein synthetic response to the ingestion of small to moderate protein doses compared to younger persons. Several studies have reported that the acute, postprandial muscle protein synthesis (MPS) response to a suboptimal protein dose is enhanced when the leucine content of the protein bolus is increased. This indicates that supplementing the lower-protein daily meals (i.e., breakfast and lunch) with leucine may represent a practical strategy to augment the MPS response to these meals and, subsequently, attenuate sarcopenic muscle mass loss over time. In addition, LC n-3 PUFA supplementation has been shown to enhance the MPS response to amino acid infusion older adults suggesting that combined leucine and LC n-3 PUFA supplementation be particularly effective for improving daily MPS, muscle mass and function in older adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age: ≥65 y
- •Sex: males and females
- •Low muscle mass (assessed via bioelectrical impedance analysis using cut-offs from Janssen, 2004) and/or low handgrip strength (< 30 kg men, <20kg women)
排除标准
- •BMI >35 kg/m2
- •Cancer - malignancy in the past 5 years
- •Multiple Sclerosis, Parkinsons Disease
- •Chronic kidney disease
- •Liver failure
- •Conditions that will affect ability to consume, digest and/or absorb the study drink (i.e. cows milk protein allergy, inflammatory bowel disease)
- •Cognitive function < 21 on Mini-Mental State Examination
- •Excess alcohol intake
- •Regular resistance training
- •Total walking incapacity
- •Musculoskeletal or neuromuscular impairments that could interfere with strength testing
- •Medications interfering with muscle metabolism
- •Adherence to a high energy or high protein diet three months before starting and during the study. Use of protein containing or amino acid containing nutritional supplements three months before starting and during the study.
- •High consumers of oily fish.
- •Weight change > 3 kg past 3 months
研究组 & 干预措施
Placebo
Protein-free, LC n-3 PUFA-free juice based supplement
干预措施: Placebo (Dietary Supplement)
Leucine-enriched protein
Juice based supplement containing leucine-enriched protein
干预措施: Leucine-enriched protein (Dietary Supplement)
Leucine-enriched protein + LC n-3 PUFA
Juice based supplement containing leucine-enriched protein and LC n-3 PUFA
干预措施: Leucine-enriched protein (Dietary Supplement)
Leucine-enriched protein + LC n-3 PUFA
Juice based supplement containing leucine-enriched protein and LC n-3 PUFA
干预措施: LC n-3 PUFA (Dietary Supplement)
结局指标
主要结局
Appendicular skeletal muscle mass
时间窗: 6 months
Assessed via dual energy x-ray absorptiometry
次要结局
- Muscle protein synthesis(6 months)
- Thigh muscle mass(6 months)
- Isometric knee extension strength(6 months)
- Physical performance(6 months)
- Metabolomics(6 months)
- Transcriptomics(6 months)
研究者
Prof Helen M Roche
Professor Helen Roche
University College Dublin