Combined Nutrient Intake and Muscle Protein Synthesis

Maastricht University Medical Center1 site in 1 country48 target enrollmentJanuary 2011

ConditionsAging

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Aging
Sponsor: Maastricht University Medical Center
Enrollment: 48
Locations: 1
Primary Endpoint: Muscle protein synthesis
Status: Completed
Last Updated: 14 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether combined nutrient intake plays an important role in stimulation of the muscle protein growth in elderly people; and whether it represent effective strategies to overcome the impaired muscle protein synthesis in elderly when compared with young subjects.

Registry

clinicaltrials.gov

Start Date

January 2011

End Date

July 2011

Last Updated

14 years ago

Study Type

Interventional

Study Design

Parallel

Sex

Male

Investigators

Sponsor

Maastricht University Medical Center

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•70-85 years or 18-30 years
•BMI \< 30

Exclusion Criteria

•Type II diabetes
•All co morbidities interacting with mobility and muscle metabolism of the lower limbs
•Use of anticoagulants
•Patients suffering from Phenylketonuria
•Participation in any regular exercise programme

Outcomes

Primary Outcomes

Muscle protein synthesis

Time Frame: 6 h postprandial period

Muscle protein synthesis will be expressed as fractional synthetic rate (FSR) by dividing the increment in enrichment in the product, i.e. protein-bound C13phe, by the enrichment of the precursor (=plasma availability).