A Machine Learning Prediction Model for Postoperative Acute Kidney Injury in Non-Cardiac Surgery Patients

Recruiting

• Conditions: Kidney Injury, Acute

• Registration Number: NCT07030166
• Lead Sponsor: Lanyue Zhu

Brief Summary

Primary objectives of this study is to develop and validate a predictive model for acute kidney injury after non-cardiac surgery based on machine learning. Secondary objectives of this study is to incorporate frailty assessment as a new predictor into the model and measure its incremental value was measured.

Detailed Description

The data of this study are divided into two parts: retrospective and prospective. The retrospective data were from the electronic medical records of adult patients who underwent non-cardiac surgery during hospitalization from July 2015 to June 2025. The ratio of the training set, the internal validation set and the test set was 7:1:2. The prospective data is an external (temporal) validation set. Data collection began in July 2025 and is expected to end in February 2026

Study Timeline

• Study First Submitted: 2025-06-07
• Study First Submitted QC: 2025-06-19
• Study First Posted: 2025-06-22
• Study Start: 2025-07-01
• Status Verified: 2025-08
• Last Update Submitted: 2025-08-13
• Last Update Posted: 2025-08-19
• Primary Completion: 2026-12-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 2500

Inclusion Criteria

• 18 years old or above
• Undergo non-cardiac surgery

Exclusion Criteria

• At least one measurement of serum creatinine (SCr) was not conducted before and after the operation
• End-stage renal disease (ESRD) that has received dialysis within the past year
• Baseline SCr ≥ 4.5 mg/dl (because the clinical criteria for AKI based on elevated SCr may not be applicable to these patients)
• Acute kidney injury occurred within 7 days before the operation
• The operation time is less than 2 hours

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute kidney injury	Within 7 days after the operation

Secondary Outcome Measures

Name	Time	Method
Postoperative mortality	Perioperative period
Hospitalization costs	Perioperative period
Hospital stays	Perioperative period
Postoperative complications	Perioperative period

Trial Locations

Locations (1)

Zhongda Hospital Southeast University; 🇨🇳 Nanjing, China