Developing a biomarker for anxiety disorders

Not Applicable

Recruiting

• Conditions: Anxiety; Panic; Simple Phobia; Generalized Anxiety; Social Anxiety; Psychological Distress; Mental Health - Anxiety; Mental Health - Studies of normal psychology, cognitive function and behaviour; Mental Health - Other mental health disorders

• Registration Number: ACTRN12620001222932
• Lead Sponsor: niversity of Otago

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-11-16
• Last Update Posted: 12 July 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

We will recruit healthy participants.
Inclusion Criteria:
1.Capable of understanding and signing an informed consent
2.Aged 18-40 years on the day of consent.
3.Volunteers with no major illness in the previous 30 days
4.With no regular use of psychotropic medication in the last 12 months
5.No use of alcohol in the 24 hours before testing
For the clinical comparison, patients with DSM-5 generalized anxiety (GAD); and social anxiety disorder (SAD) will be recruited for our project
Inclusion Criteria:
1. 18-40 years old
2. suffering from ongoing symptoms of anxiety, fear, or panic and who are intending to seek treatment for this
3. otherwise be healthy (with no major illness in the previous 30 days)
4. with no regular use of psychotropic medication in the last 6 months and
5. no use of alcohol in the 24 hours before testing.

Exclusion Criteria

Healthy Volunteers:
Exclusion Criteria:
- Susceptibility to photosensitivity
- A history of seizure
- Any metal in your body, e.g., cardiac pacemaker, cochlea implant, intracranial vessel clips, artificial heart valve or vascular stent; a history of metal fragments in the eye; shrapnel within the body
- Are either pregnant or think you might be
- A history of claustrophobia
- Have received any medical or psychological treatment for anxiety, depression or emotional disorder within the last 12 months.
- Have a prior history of drug abuse
- Are suffering from acute or chronic physical disease such as heart and lung disease, influenza, diabetes, acute infections
- Are recovering from an accident, injury or operation.
Patient Volunteers (GAD and SAD)
Exclusion Criteria:
- Susceptibility to photosensitivity
- A history of seizure
- Any metal in your body, e.g., cardiac pacemaker, cochlea implant, intracranial vessel clips, artificial heart valve or vascular stent; a history of metal fragments in the eye; shrapnel within the body
- Are either pregnant or think you might be
- A history of claustrophobia
- Have a prior history of drug abuse
- Are suffering from acute or chronic physical disease such as heart and lung disease, influenza, diabetes, acute infections
- Are recovering from an accident, injury or operation.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in brain networks assessed using fMRI [30 minutes after intervention];Compare the fMRI changes between healthy and diseased brains specially the task related changes in hippocampus and insula.[30 minutes ];Changes in HAM-A and STAI-T because of acute administration of anxiolytic drugs. (This is a composite outcome) [2 hour after dosing.]

Secondary Outcome Measures

Name	Time	Method
se fMRI to investigate whether hippocampus is involved in anxiety processes,[2 hours after intervention];Use fMRI to investigate whether amygdala is involved in panic.[2 hours]