Pilot study to analyze the exhalation profile of patients with graft versus host disease (GvHD) of the lung after allogeneic stem cell transplantaio
- Conditions
- T86.00
- Registration Number
- DRKS00006883
- Lead Sponsor
- Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Germany, Member of the German Center for Lung Research (DZL)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Review Group (V.A. lung GvHD):
-Z.n. allogeneic stem cell or bone marrow transplantation
-a GVHD of the lung is assumed by:
> respiratory symptoms
> Change in lung function e.g. FEV1 <75% FEV1 / VCin <0.7, signs of air trapping (RV> 120%),
> Exclusion of infectious complications by CT thorax (clinical routine / no study examination), laboratory diagnostics (CRP, PCT), infectiological diagnosis (CMV PCR, blood culture, sputum, if necessary)
> CT morphological suspicion by wall thickening of the small airways or bronchiectasis
> after clinic exclusion of cardiac causes (ECG and UKG)
> if necessary. other manifestations of GVHD
comparison group
-Z.n. allogeneic stem cell or bone marrow transplantation
-not respiratory symptoms
-Agreement to study participation
Review Group (V.A. lung GvHD):
- Infectious or cardiopulmonary causes pulmonary symptoms. Exclusion by chest CT, inflammation paramters (CRP, PCT), possibly microbiological diagnosis, ECG and UKG
comparison group:
- Clinical or imaging evidence of pulmonary disease (GvHD, infections, cardiopulmonary disease) in the month prior to the examination
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences in breath condensate
- Secondary Outcome Measures
Name Time Method 1 protein concentration in blood<br>2. volatile organic compounds measured with IMS and eNose