High Intensity Interval Training after Cardiac Resynchronization Therapy: a randomised controlled trial

Completed

Conditions: Cardiac Resynchronization Therapy
Chronic Heart Failure
10019280

Registration Number: NL-OMON37928

Lead Sponsor: Maxima Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

-Written informed consent.
-Systolic heart failure due to ischemic cardiomyopathy (due to one or more myocardial infarction, as confirmed with echocardiography) or dilating cardiomyopathy (no history of myocardial infarction, no proven ischemia, no congenital heart disease and no severe valve disorder)
-Left ventricular ejection fraction < 35% before CRT.
- New York Heart Association (NYHA) classII or III before CRT

Exclusion Criteria

* Myocardial infarction or unstable angina less than 3 months prior to inclusion
* Clinical signs of decompensated heart failure
* Ventricular tachycardia or ischemia during exercise
* Participation in a training program (*2/week) in the last year
* Intracardiac shunts or congenital heart disease limiting exercise capacity
* Orthopaedic, vascular, pulmonary, neuromuscular and other disease limiting exercise capacity
* Pathological Allen test , In casu no sufficient collateral circulation to the hand, in case of radial artery cannulation.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Changes in maximal exercise capacity are assessed by changes in peak VO2<br /><br>Changes in cardiac output response to exercise before and after HIT</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To investigate the additional effects of HIT after CRT on:<br /><br>- Left ventricular function (left ventricular ejection fraction, end systolic<br /><br>volume)<br /><br>- Submaximal exercise capacity (rate of recovery of oxygen uptake after<br /><br>submaximal exercise)<br /><br>- Quality of life (Minnesota living with heart failure Questionnaire)<br /><br>- Skeletal muscle tissue oxygenation</p><br>