Effect of High Intensity Training on immune and cardiovascular responses in people living with HIV

Not Applicable

Recruiting

• Conditions: HIV Long-Term Survivors; B04.820.650.589.650.350

• Registration Number: RBR-4qcx7g3
• Lead Sponsor: niversidade Federal do Rio Grande do Norte

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-08-23
• Last Update Posted: 18 September 2023
• Study Completion: 2023-12-30

Recruitment & Eligibility

• Status: Recruiting
• Sex: Male
• Target Recruitment: Not specified

Inclusion Criteria

Men with HIV who have started antiretroviral therapy for at least 6 months; medical certificate releasing the practice of physical exercise; age between 18 and 40 years; physically active; and cell count of T lymphocytes cluster of differentiation 4 (T CD4) above 350 cells/mm³. For subjects without HIV, all criteria for people living with HIV will be used, with the exception of antiretroviral therapy and presence of HIV

Exclusion Criteria

People with HIV who have some musculoskeletal limitation that prevents them from carrying out the exercise; cardiovascular diseases; illicit drug users and/or smokers; alcoholics; do not comply with recommendations for carrying out assessments; and who do not complete the experimental protocol

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
It is expected to find a difference in the count of immune cells (leukocytes, lymphocytes, CD4, CD8, CD19, CD56) when compared to the HIV groups (HIITxMICT), for a lower cell count for the HIIT group after 24 hours of physical exercise, but not when comparing the HIVxWithout HIV (HIITxHIIT) groups, using the hemogram and immunophenotyping methods for analysis of immune cells.;It is expected to find a difference in the function of lymphocytes from the production of cytokines (IL-2, IL-4, IL-10, TNF alpha and Interferon Gamma) in cell culture, when comparing the HIV groups (HIITxMICT), for a lower cell count for the HIIT group after 24 hours of physical exercise, but not when compared to the HIVxWithout HIV (HIITxHIIT) groups, using the methods of cell culture and flow cytometry to analyze the production of lymphocytes.

Secondary Outcome Measures

Name	Time	Method
A greater reduction of cardiac autonomic control at rest is expected with a lower parasympathetic activity for the HIIT group when compared to MICT in people living with HIV and for the HIIT (HIV) group when compared to HIIT (without HIV), evaluated through the heart rate variability, using a Polar H10 heart rate transmitter together with the Elite HRV smartphone application, being analyzed at times: before exercise, immediately after and 24 hours after the end of exercise.