The effects of midazolam and flumazenil on cerebral circulation - Midazolam, flumazenil and cerebral circulation

During midazolam sedation, BIS index, MAP, CBF velocity, and transfer function gain decreased significantly compared with baseline. After administration of flumazenil, BIS index and MAP returned to the same level as baseline. However, CBF velocity showed a further significant decrease compared with midazolam sedation, and the decreased transfer function gain persisted. The present study suggest that despite complete antagonism of the sedative effects of midazolam, flumazenil dose not reverse the alterations in cerebral circulation induced by midazolam.