JPRN-UMIN000012777
Completed
未知
The effects of midazolam and flumazenil on cerebral circulation - Midazolam, flumazenil and cerebral circulation
Division of Hygiene, Department of Social Medicine, Nihon University School of Medicine0 sites20 target enrollmentJanuary 7, 2014
Conditionshealthy subjects
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- healthy subjects
- Sponsor
- Division of Hygiene, Department of Social Medicine, Nihon University School of Medicine
- Enrollment
- 20
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
During midazolam sedation, BIS index, MAP, CBF velocity, and transfer function gain decreased significantly compared with baseline. After administration of flumazenil, BIS index and MAP returned to the same level as baseline. However, CBF velocity showed a further significant decrease compared with midazolam sedation, and the decreased transfer function gain persisted. The present study suggest that despite complete antagonism of the sedative effects of midazolam, flumazenil dose not reverse the alterations in cerebral circulation induced by midazolam.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •1\) Not satisfy selection criteria noted above. 2\) Volunteers having allergic factors to foods and/or drugs.
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Not Applicable
Cortico-cortical Connectivity During Midazolam Sedation in Humans; a TMS/EEG StudyHealthyNCT00734006University of Wisconsin, Madison20
Completed
Phase 2
Effect of Midazolam on perception and consciousness during surgeryIntraoperative awareness.Other symptoms and signs involving cognitive functions and awarenessIRCT201207086480N3vice chancellory for research, Shahrekord University of Medical Sciences154
Completed
Not Applicable
Effects of Flumazenil on Brain ExcitabilityStrokeHealthyNCT00015678National Institute of Neurological Disorders and Stroke (NINDS)7
Completed
Not Applicable
Relationships between electroencephalogram and plasma concentration of midazolam after induction of anesthesiaPatients undergoing operations under general anesthesia, not limited to specific diseasesJPRN-UMIN000001293Department of Anesthesiology, Osaka City University Graduate School of Medicine30
Withdrawn
Not Applicable
Effect of Sedatives on Regional Cerebral Oxygen SaturationCerebral Ischemia-HypoxiaNCT02966743Gachon University Gil Medical Center