Relationships between electroencephalogram and plasma concentration of midazolam after induction of anesthesia - Midazolam and electroencephalogram
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 30
研究概览
简要总结
Plasma and simulated effect site concentrations of midazolam decreased rapidly and were significantly higher in the large-dose group than in the small-dose group (P = 0.005 and < 0.001, respectively). Both BIS and relative beta ratio decreased after induction and remained between 60 and 70, between -1.8 and -1.2, respectively. No differences were observed in BIS, relative beta ratio or 95% spectral edge frequency between the two groups, either. Relative beta ratio significantly correlated with BIS in both groups (r2 = 0.66 and 0.78, respectively, P < 0.001 for both). The electroencephalographic spectral power density in the beta- (≥13 and <30 Hz) band was significantly increased after induction, besides being significantly larger in the large-dose group than in the small-dose group (P = 0.009).
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 70years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1) patients undergoing thoracotomy or lapalotomy, 2) patients with advanced hepatic or renal dysfunction, 3) taking cytochrome P4503A inducers or inhibitors preoperatively, 4) predicted difficulty in tracheal intubation, 5) receiving CYP3A inhibitors during anesthesia, 6) receiving medications affecting electroencephalogram