Quantifying the effect of the sedative alprazolam on brain electrical activity using the Brain Anaesthesia Response monitor

Completed

• Conditions: Anaesthetic depth using processed electroencephalography; Anaesthesiology - Anaesthetics; Neurological - Studies of the normal brain and nervous system

• Registration Number: ACTRN12611000144910
• Lead Sponsor: Swinburne University of Technology

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-02-08
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 15

Inclusion Criteria

non-smoker, no history of anxiety, depression or other psychiatric disorder, no history of epilepsy or other neurological disorder known to affect resting EEG

Exclusion Criteria

consumption of any pharmaceutical product/medicine in last 30 days, consumption of vitamin complex or herbal extract withion last 30 days, history of alcohol or drug abuse

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in BAR index (mean pole location)[BAR index recorded for 5 minutes every hour for 3 hours following drug administration]

Secondary Outcome Measures

Name	Time	Method
Changes from baseline in relative delta, theta, alpha, beta and gamma power will be assessed using repeated measures ANOVA.[Assessed every hour for 3 hours following drug administration]