NCT02705911
Completed
Not Applicable
Isometric Handgrip Exercise: a New Non-pharmacological Tool in the Management of High Blood Pressure?
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hypertension
- Sponsor
- KU Leuven
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- change in office blood pressure at 8 weeks of follow-up
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The purpose of this RCT which will be performed in 60 healthy adults is I. To assess the training effects of 8 weeks of isometric handgrip exercise on BP; and to test whether it yields at least similar effects on BP compared to current exercise recommendations.
II. To assess whether isometric handgrip training yields larger BP reductions beyond the supervised training period at 6 months of follow-up.
III. To determine whether changes in BP following acute exercise and chronic training can be explained by changes in important physiological mechanisms known to mediate or to be associated with BP?
Investigators
Véronique Cornelissen
PhD
KU Leuven
Eligibility Criteria
Inclusion Criteria
- •not physically active (\< 3 hours of moderate to high levels of PA/week) low cardiovascular risk according to current guidelines (Mancia et al J Hypertens 2013) will be recruited through advertisements. The latter is defined as:
- •\>115 mmHg \< systolic BP \< 139 mmHg and/or 75 mmHg\< diastolic BP\<90mmHg in the presence of 0 to a maximum of three other cardiovascular risk factors, excluding diabetes Or
- •139 mmHg \< systolic BP \< 160 mmHg and/or 90 mmHg\<DBP\< 100 mmHg in the absence of other cardiovascular risk factors
Exclusion Criteria
- •current smoker
- •pregnancy
- •presence of other cardiovascular disease, pulmonary disease or metabolic disease
- •inability to perform a standard exercise program due to mental/physical disability.
- •use of antihypertensive drugs
Outcomes
Primary Outcomes
change in office blood pressure at 8 weeks of follow-up
Time Frame: 8 weeks - 6 months
Secondary Outcomes
- change in exercise tolerance (peakVO2 in ml/min/kg) at 8 weeks of follow-up(8 weeks - 6 months)
Study Sites (1)
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