Combined and Isolated Effects of Sleep Deprivation and Alcohol Intake on Exercise Performance in Humans.

Not Applicable

Completed

• Conditions: Alcohol Intake; Sleep Deprivation
• Interventions: Other: Alcohol intake; Other: Sleep deprivation

• Registration Number: NCT02117193
• Lead Sponsor: Federal University of Rio Grande do Sul

Brief Summary

Although the effects of acute alcohol intake and sleep deprivation on exercise performance lacks evidence in the literature, in many situations, they occur simultaneously. Once the alcohol affects physiological processes, the processes that occur during sleep can be impaired, such as: suppression of GH release, action of neurotransmitters and neuromodulators in the CNS, changes in the proportion of sleep stages and may lead to suppression of REM sleep. These changes promote a significant functional impairment such as a reduction in alertness and modification in reaction time, which affects the performance of any activity of daily and professional life. However, the combined effects on the physical performance variables, such as aerobic and neuromuscular performance lack of evidence in the literature.

Detailed Description

Ten subjects were randomized in four situations after familiarization and control situation: (1) alcohol intake combined with sleep normal; (2) alcohol intake combined with sleep deprivation; (3) placebo intake combined with sleep normal and (4) placebo intake combined with sleep deprivation.

Study Timeline

• Study Start: 2013-10
• Study First Submitted: 2014-04-14
• Study First Submitted QC: 2014-04-15
• Study First Posted: 2014-04-17
• Primary Completion: 2015-05
• Study Completion: 2015-05
• Results First Submitted: 2016-05-10
• Results First Submitted QC: 2016-08-01
• Results First Posted: 2016-09-22
• Status Verified: 2016-10
• Last Update Submitted: 2016-10-27
• Last Update Posted: 2016-12-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

• Physical active men

Exclusion Criteria

• AUDIT questionnaire above 15 points
• Nocturnal Chronotype
• Skeletal muscle injuries in upper and lower limb
• Metabolic and cardiovascular disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Alcohol intake	Alcohol intake	1 g/kg of etanol combined. Beer without alcohol in the same volume will be used to placebo condition.
sleep deprivation	Alcohol intake	one night of sleep deprivation will be compared to 8h of normal sleep.
sleep deprivation	Sleep deprivation	one night of sleep deprivation will be compared to 8h of normal sleep.
Alcohol intake	Sleep deprivation	1 g/kg of etanol combined. Beer without alcohol in the same volume will be used to placebo condition.

Primary Outcome Measures

Name	Time	Method
Aerobic Performance	After each sequence, up to 8 hours	Aerobic performance will be determined through the subject's heart rate
Neuromuscular Performance	After each sequence, up to 8 hours	knee extensor isometric torque
Biochemical Responses	After each sequence, up to 8 hours	Glucose after each situation in the morning

Secondary Outcome Measures

Name	Time	Method
Profile of Mood States	6 months
Hydration Status	After each sequence, up to 8 hours	Urine Specific Gravity
Breath Alcohol	6 months

Trial Locations

Locations (1)

Exercise Research Laboratory; 🇧🇷 Porto Alegre, Rio Grande do Sul, Brazil