Effects of a short burst of high-intensity exercise versus moderate-intensity exercise combined with restriction to blood flow to the exercising leg muscles on cardiovascular health in people with a combination of risk factors of cardiovascular disease (metabolic syndrome)

Not Applicable

• Conditions: metabolic syndrome; Metabolic and Endocrine - Metabolic disorders; Cardiovascular - Other cardiovascular diseases; Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation

• Registration Number: ACTRN12621000088842
• Lead Sponsor: Flinders University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-02-01
• Last Update Posted: 8 February 2021

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Inclusion Criteria:

-Male and female (age 30 to 65 years)
-Diagnosed with MetS according to the IDF criteria
-Be willing to participate in either of the interventions
-Be cleared to undertake either exercise intervention
-Engaged in less than 150 minutes of moderate-intensity exercise/physical activity per week
-be willing to undergo a pre-exercise screening evaluation according to the Australian Pre-exercise Screening System (APSS) (SMA 2005) and cleared to undertake either exercise program

Exclusion Criteria

-Have been sent for medical clearance, based on the APSS screening guidelines, and clearance to participate is not provided.
-Diagnosed with either Type 1 or 2 diabetes
-Smokers or have a history of smoking within the past 2 years
-Consume 2 standard alcohol beverages per day
-Pregnant
-Participants with pacemakers
-Unstable angina
-Recent myocardial infarction (last 4 weeks)
-Severe valvular heart disease
-Uncompensated heart failure
-Pulmonary disease
-Uncontrolled hypertension
-Kidney failure
-Cardiomyopathy
-Medications likely to affect insulin sensitivity (i.e. glucocorticoids, oral contraceptives, sulfonylureas, etc.)
-Orthopaedic limitations prohibiting engagement in physical activity

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome 1: central arterial stiffness<br>Pulse wave analysis will be measured using an automated device (SphygmoCor, AtCor Medical Pty Ltd., West Ryde, Australia) to assess arterial stiffness and central blood pressure indices. For pulse wave analysis, a cuff will be placed around the arm between the elbow and shoulder, and will be partially inflated to obtain a measure of central blood pressure. [Timepoint: Baseline, after a single exercise session, and after 8 weeks<br>];Primary outcome 2: central arterial stiffness<br>Pulse wave velocity will be measured using an automated device (SphygmoCor, AtCor Medical Pty Ltd., West Ryde, Australia) to assess arterial stiffness. For pulse wave velocity, a cuff will be placed around the upper thigh, and a pen-like tonometer pressure sensor on the participant’s neck to derive a measure of arterial stiffness.<br>[Timepoint: Baseline, after a single exercise session, and after 8 weeks]