PRP Intrauterine Infusion in Thawed Embryo Cycles

Phase 4

Completed

• Conditions: Evaluations
• Interventions: Biological: Normal saline; Biological: Platelet rich plasma intrauterine infusion

• Registration Number: NCT03734042
• Lead Sponsor: Tanta University

Brief Summary

All patients prepared to thawed embryo transfer were classified into 2 groups one group will receive platelet rich plasma (PRP) infusion intrauterine and the other group will not receive platelet rich plasma (PRP) infusion

Detailed Description

Patients candidates for Thawed embryo transfer with Repeated implantation failure were recruited from 3 centers and classified into 2 groups:

Group I: Will receive platelet rich plasma (PRP) intrauterine infusion at day 11

Group II: Not receiving platelet rich plasma (PRP)

Study Timeline

• Study First Submitted: 2018-11-06
• Study First Submitted QC: 2018-11-06
• Study First Posted: 2018-11-07
• Study Start: 2018-12-01
• Primary Completion: 2021-10-31
• Study Completion: 2021-10-31
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-26
• Last Update Posted: 2021-11-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 102

Inclusion Criteria

• Patients age 20-35 years
• Patients with previous implantation failure
• Patients with thin endometrium<7 mm

Exclusion Criteria

• Patients older than 40 years
• Patients with fresh embryo transfer
• Patients with abnormal uterine cavity septate, or bicornuate uterus
• Patients with abnormal male factor or tubal factor
• Patients with abnormal embryos grade B or C.
• Patients with immunological disorders as thyroidits or systemic lupus or rheumatoid arthritis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	Normal saline	These patients will receive intrauterine normal saline infusion at day 11
PRP group	Platelet rich plasma intrauterine infusion	These patients will receive platelet rich plasma intrauterine infusion at day 11

Primary Outcome Measures

Name	Time	Method
Endometrial thickness	8 days	The increase in endometrial thickness at day of ET
Pregnancy rate	15 days	Number of cases who got pregnant

Trial Locations

Locations (1)

Ayman Shehata Dawood; 🇪🇬 Tanta, Egypt