Assessing the effectiveness of Methotrexat versus Azathioprine on disease activity index in Lichen planopilaris patients

Phase 3

• Conditions: ichen planopilaris.; Lichen planopilaris; L66.1

• Registration Number: IRCT20191006045005N2
• Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 26 April 2021

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

Patients with local disease that does not respond to topical treatment after one month
Patients with extensive scalp involvement as the first line treatment.
Patients should have discontinued any previous systemic medication 1 month prior to admission to the study.
Ages 18-65

Exclusion Criteria

Pregnancy or lactation
Leukocytes less than 3000 (leukopenia of any etiology)
Platelets less than 100000
Hemoglobin less than 9
Liver enzymes more than 2 time the reference limit
Positive for viral hepatitis tests
Consumption of Allopurinol

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ichen planopilaris Activity Index. Timepoint: Measurement of Lichen planopilaris Activity Index at the beginning of the study (prior to treatment) and 2, 4, and 6 months after the treatment. Method of measurement: Using an oral questionnaire and clinical examination of patient for items in lichen planopilaris activity index.;Photography. Timepoint: Photography at the beginning of the study(prior to treatment) and 2,4 and 6 month after treatment. Method of measurement: Professional camera for dermatologist.;Dermoscopy. Timepoint: Dermoscopy at the beginning of the study(prior to treatment) and 2,4 and 6 month after treatment. Method of measurement: Handyscope fotofinder system.