A Clinical trial to compare the effect of methotrexate alone and the effect of giving methotrexate along with atorvastatin for the treatment of psoriasis vulgaris
- Conditions
- Health Condition 1: L400- Psoriasis vulgaris
- Registration Number
- CTRI/2018/10/016101
- Lead Sponsor
- SRM MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTRE
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
Patients presenting to the in-patient and out-patient department of dermatology, SRM medical college hospital, Potheri
With chronic plaque type psoriasis diagnosed clinically &histopathologically (wherever necessary) by a dermatologist
Having PASI score > 12
Patients who are statin naïve
acute or chronic liver disease
myopathies
family history of hereditary muscular disorders (assessed by history, clinical examination, raised serum alanine aminotransferase and creatinine phophokinase thrice the upper limit)
uncontrolled hypertension
with known allergy to any of the treatment
patients taking any drug that might interact with statins
already taking statins
impaired renal function or creatinine >2.0 mg/dl
active infection or WBC > 10,000/cmm
pregnant and lactating females
females and males who did not complete their family
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method reduction in PASI score more than or equal to 50% from intial PASITimepoint: 6 months
- Secondary Outcome Measures
Name Time Method reduction in PASI score more than or equal to 75% from intial PASITimepoint: 9 months