The effect of methotrexate and cyclosporine on lichenplanopilaris

Phase 2

Recruiting

• Conditions: ichen planopilaris.; Lichen planopilaris; L66.1

• Registration Number: IRCT20190717044256N1
• Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 October 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

Scalp involvement more than 10%
Local disease (<10%Involvement) resistant to 3-month topical treatment or 6-months systemic treatment
The patients should be stopped all systemic or topical medications at least one month before enrollment to the study

Exclusion Criteria

Pregnancy lactation
Hb<9mg/dl
Wbc<4000
Plt<100000
Liver enzymes 3 times more than upper limit of normal
Positive viral hepatic tests
Renal failure
Uncontrolled blood pressure
Administration of another immunosuppressive or topical medication by other physicians
Elevated serum creatinine >50% or >25% by lower doses of drug(25-50% over 2weeks)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ichen planopilaris activity. Timepoint: Before and after 2,4,6 months after intervention. Method of measurement: Checklist of criteria in lichen planopilaris activity index ; Lichen planopilaris activity index is measured by this formula:LPPAI = (itch + pain + burn ) / 3 + (scalp erythema + perifollicular erythema +perifollicular scale) / 3 + 2.5(pull test) + 1.5(spreading / 2).;Standardized global photography. Timepoint: Before and after intervention. Method of measurement: Based on scoring by two dermatologists.