Symptomatic response to proton pump inhibitor (PPI) in patients with non-ulcer dyspepsia

Completed

• Conditions: Dyspepsia, upper gastrointestinal tract disease; Digestive System; Dyspepsia

• Registration Number: ISRCTN32863375
• Lead Sponsor: niversity of Glasgow (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-09-08
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 105

Inclusion Criteria

1. Upper gastrointestinal (GI) symptoms of more than 3 months duration
2. No evidence of peptic ulcer disease, erosive oesophagitis or hiatus hernia in endoscopy
3. H. pylori negative on histology and urease test
4. Aged 24 - 72 years, either sex

Exclusion Criteria

1. Current use of non-steroidal anti-inflammatory drugs or other medication
2. Any recognised cause of upper GI symptoms

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in overall symptom score measured by modified Glasgow Dyspepsia Severity Score. All these measurements will be taken on baseline and at the end of 2 weeks.

Secondary Outcome Measures

Name	Time	Method
Predictors of response to lansoprazole including symptom severity score, symptom characteristics, oesophageal 24h pH metry and oesophageal manometry profiles and body mass index (BMI). All these measurements will be taken on baseline.