TIMP-2 and IGFBP7 for the Prediction of the Cardiac Surgery Associated Acute Kidney Injury
Completed
- Conditions
- Acute Kidney Injury
- Registration Number
- NCT02054546
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Brief Summary
The purpose of this study is to analyze the new biomarkers (TIMP-2 and IGFBP-7) of tubular renal cell damage for the prediction of the Cardiac Surgery Associated acute kidney injury.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 110
Inclusion Criteria
- planned cardiac surgery
Exclusion Criteria
- renal dialysis
- minors
- emergency
- no cardiopulmonary bypass
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method AKI-stadium 1 (KDIGO) 30 days
- Secondary Outcome Measures
Name Time Method all cause mortality 30 days
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What is the predictive accuracy of TIMP-2 and IGFBP7 biomarkers for cardiac surgery-associated acute kidney injury compared to traditional markers like serum creatinine?
How do TIMP-2 and IGFBP7 expression levels correlate with renal tubular cell damage mechanisms in post-cardiac surgery acute kidney injury patients?
What are the potential adverse events associated with TIMP-2 and IGFBP7 biomarker testing in cardiac surgery populations and how are they managed?
Are there combination biomarker approaches involving TIMP-2 and IGFBP7 that improve risk stratification for acute kidney injury after cardiac surgery?
What is the clinical utility of TIMP-2 and IGFBP7 in predicting acute kidney injury subtypes following cardiac surgery compared to other renal injury biomarkers like NGAL or KIM-1?
Trial Locations
- Locations (1)
Universitätsspital Basel
🇨🇭Basel, Basel-Stadt, Switzerland
Universitätsspital Basel🇨🇭Basel, Basel-Stadt, Switzerland