Glaucoma, Visual Field Loss, and Their Association With Life Space in Older Adults
- Conditions
- Primary Open Angle Glaucoma
- Interventions
- Diagnostic Test: Life Space QuestionnaireDiagnostic Test: Low Luminance QuestionnaireDiagnostic Test: Contrast sensitivity under dim illuminationDiagnostic Test: Visual field under dim illumination (MAIA)Diagnostic Test: Macular Pigment Optical Density (MPOD)Diagnostic Test: Dark Adaptation
- Registration Number
- NCT04396002
- Lead Sponsor
- University of Alabama at Birmingham
- Brief Summary
Mobility refers to a person's purposeful movement through the environment from one place to another and can be conceptualized as a continuum from bed bound (immobility) on one extreme to making excursions to distant locations on the other extreme. Primary open-angle glaucoma (POAG) is a chronic, progressive optic neuropathy that can lead to gradual loss of vision in the peripheral field and central vision. Older adults with POAG have an increased risk for motor vehicle collisions and falls. Moreover, existing studies suggest that patients with POAG exhibit more postural sway while standing as measured by a balance platform and also tend to walk more slowly than those who are normally sighted and free of ocular disease. While these disturbances likely influence mobility, there has been little research directly assessing the impact of POAG on mobility. This study will assess the impact of POAG on life space (one aspect of mobility) and will determine whether difficulties with life space are associated with difficulties experienced under conditions of dim lighting.
- Detailed Description
Aim 1: To determine whether differences exist between people with healthy eyes and patients with POAG in seeing under dim illumination (Low Luminance Questionnaire) and to determine whether such differences are associated with life space.
Aim 2: To determine whether differences exist between people with healthy eyes and patients with POAG in seeing under dim illumination (objective measures of visual function) and to determine whether such differences are associated with life space.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 100
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Primary Open-Angle Glaucoma Contrast sensitivity under dim illumination Patients diagnosed with primary open-angle glaucoma. Primary Open-Angle Glaucoma Dark Adaptation Patients diagnosed with primary open-angle glaucoma. Primary Open-Angle Glaucoma Macular Pigment Optical Density (MPOD) Patients diagnosed with primary open-angle glaucoma. Control Life Space Questionnaire Participants with healthy eyes. Primary Open-Angle Glaucoma Life Space Questionnaire Patients diagnosed with primary open-angle glaucoma. Primary Open-Angle Glaucoma Visual field under dim illumination (MAIA) Patients diagnosed with primary open-angle glaucoma. Control Low Luminance Questionnaire Participants with healthy eyes. Control Visual field under dim illumination (MAIA) Participants with healthy eyes. Primary Open-Angle Glaucoma Low Luminance Questionnaire Patients diagnosed with primary open-angle glaucoma. Control Macular Pigment Optical Density (MPOD) Participants with healthy eyes. Control Contrast sensitivity under dim illumination Participants with healthy eyes. Control Dark Adaptation Participants with healthy eyes.
- Primary Outcome Measures
Name Time Method Differences in visual sensitivity under dim illumination between controls and patients Through study completion, an average of 1 year Participants will be presented with targets at different locations in their visual fields under dim illumination.
Assessment of the relationship between each the measure of visual function and self-reported visual function under dim illumination Through study completion, an average of 1 year The relationship between each of the measures of visual function (dark adaptation, contrast sensitivity functions, visual fields under dim illumination, and MPOD) and self-reported visual performance under dim illumination (Low Luminance Questionnaire) will be assessed.
Assessment of life space measured with the Life Space Questionnaire Through study completion, an average of 1 year The Life Space Questionnaire is a 9-item questionnaire that assesses how much a person gets out and about and the spatial extent of the person's typical life space, i.e., what is the usual range of places in which the person engages in activities within the designated time frame. Patients are asked to respond either Yes or No.
Assessment of vision under low luminance conditions Through study completion, an average of 1 year The Low Luminance Questionnaire is a 32-item questionnaire that assesses how participants see under dim illumination and how well they can perform different tasks (e.g. reading, driving). Patients are asked to select a response among different choices on a Likert scale that ranges from 1 to 5, 1 to 6, 1 to 7, or 1 to 8 depending on the question. A response of "1" indicates that the participant experiences no difficulty while increasingly higher numbers indicate increasing amounts of difficulty.
Differences in contrast sensitivity functions between controls and patients Through study completion, an average of 1 year Participants will be presented with targets of different spatial frequency at different contrasts. Their sensitivity at each spatial frequency will be recorded/
Assessment of the relationship between each the measure of visual function and life space Through study completion, an average of 1 year The relationship between each of the measures of visual function (dark adaptation, contrast sensitivity functions, visual fields under dim illumination, and MPOD) and life space (Life Space Questionnaire will be assessed.
Differences in dark adaptation between controls and patients Through study completion, an average of 1 year Once participants have adapted to a dark environment, they will be exposed to a bright flash of light. The time needed to recover their visual sensitivity will be measured (rod-intercept time).
Differences in Macular Pigment Optical Density between controls and patients Through study completion, an average of 1 year Participants will fixate on a target while their MPOD is assessed. The MPOD is measured using the Heidelberg optical coherence tomography (OCT) MPOD module. Two different light sources are directed to the back of the eye. The light is reflected back and the OCT/MPOD computes the difference in the reflectance of the two lights which is an estimate of the density of macular pigment.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Alabama Birmingham
🇺🇸Birmingham, Alabama, United States