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An Active Approach to Treat Amblyopia: Perceptual Learning and Video Games

Not Applicable
Completed
Conditions
Amblyopia
Registration Number
NCT01115283
Lead Sponsor
University of California, Berkeley
Brief Summary

Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. This study uses psychophysical measures to study neural plasticity in both adults and children with amblyopia.

Detailed Description

Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. Our previous findings (see CITATIONS) show that the adult amblyopic brain is still plastic and malleable, suggesting that active approach is potential useful in treating amblyopia. The goal of this project is to assess the limits and mechanisms of neural plasticity in both normal and amblyopic spatial vision. This study uses psychophysical measures to study neural plasticity in both adults and children with amblyopia. Research participants will be asked to practice a visual discrimination task (perceptual learning) or to play video games with the amblyopic eye for a period of time. A range of visual functions will be monitored during the course of treatment.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
50
Inclusion Criteria
  • adults and children (>5 years old) with normal vision or amblyopia
  • amblyopia: interocular VA difference of at least 0.1 logMAR
Exclusion Criteria
  • any ocular pathological conditions, nystagmus

Study & Design

Study Type
INTERVENTIONAL
Study Design
CROSSOVER
Primary Outcome Measures
NameTimeMethod
Amblyopic vision9 months

Improvement in amblyopic vision : visual acuity and stereoacuity

Secondary Outcome Measures
NameTimeMethod
Spatial vision9 months

Improvement in spatial vision (eg. contrast sensitivity, positional acuity and spatial attention)

Temporal vision9 months

Improvement in temporal processing and temporal vision

Trial Locations

Locations (1)

Minor Hall 486, School of Optometry, University of California, Berkeley

🇺🇸

Berkeley, California, United States

Minor Hall 486, School of Optometry, University of California, Berkeley
🇺🇸Berkeley, California, United States

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