An Active Approach to Treat Amblyopia: Perceptual Learning and Video Games
- Conditions
- Amblyopia
- Registration Number
- NCT01115283
- Lead Sponsor
- University of California, Berkeley
- Brief Summary
Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. This study uses psychophysical measures to study neural plasticity in both adults and children with amblyopia.
- Detailed Description
Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. Our previous findings (see CITATIONS) show that the adult amblyopic brain is still plastic and malleable, suggesting that active approach is potential useful in treating amblyopia. The goal of this project is to assess the limits and mechanisms of neural plasticity in both normal and amblyopic spatial vision. This study uses psychophysical measures to study neural plasticity in both adults and children with amblyopia. Research participants will be asked to practice a visual discrimination task (perceptual learning) or to play video games with the amblyopic eye for a period of time. A range of visual functions will be monitored during the course of treatment.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
- adults and children (>5 years old) with normal vision or amblyopia
- amblyopia: interocular VA difference of at least 0.1 logMAR
- any ocular pathological conditions, nystagmus
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Amblyopic vision 9 months Improvement in amblyopic vision : visual acuity and stereoacuity
- Secondary Outcome Measures
Name Time Method Spatial vision 9 months Improvement in spatial vision (eg. contrast sensitivity, positional acuity and spatial attention)
Temporal vision 9 months Improvement in temporal processing and temporal vision
Trial Locations
- Locations (1)
Minor Hall 486, School of Optometry, University of California, Berkeley
🇺🇸Berkeley, California, United States
Minor Hall 486, School of Optometry, University of California, Berkeley🇺🇸Berkeley, California, United States