Neutrophil to lymphocyte Ratio, Platelet to lymphocyte ratio and serum lactate asprognostic indicators in patients with acute exacerbations of chronic obstructive pulmonarydisease.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 114
- 试验地点
- 1
- 主要终点
- exacerbation of COPD
研究概览
简要总结
Patients admitted with the diagnosis of AECOPD
satisfying inclusion and exclusion criteria during the study period will be included, socio socio-
demographic and clinical data of patients will be collected and recorded in case proforma upon
admission. Details of comorbidities will be obtained from clinical notes. Breathlessness will be graded
according to the modified Medical Research Council dyspnea (MMRC) score and patients will be
divided in based on group A, B, E. History of smoking, Occupational exposure to smoke, Family
History of COPD will be obtained. Routine investigations like CBC, ABG, chest radiograph at the time
of admission will be done as a standard of care and results shall be recorded in the case proforma. The
patient will be followed up during the entire hospital stay. Clinical Outcomes will be categorized as
ICU admission, duration of admission, mortality. Later the NLR, PLR and serum lactate levels at the
time of admission will be correlated with the clinical outcome of the patient. Lactate level blood (ABG)
test will be considered as a standard care of test in patient of acute Exacerbation of COPD
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •All patients above 18 years of age All patients who are diagnosed case of COPD.
排除标准
- •Patient diagnosed with Bronchial Asthma Patient Diagnosed with Bronchiectasis Patient Diagnosed with Active pulmonary Tuberculosis Patient diagnosed with Malignancy.
结局指标
主要结局
exacerbation of COPD
时间窗: 9 months
3) To assess the prognostic value of lactate levels in predicting in-hospital mortality in
时间窗: 9 months
patients with acute exacerbation of COPD
时间窗: 9 months
acute exacerbation of COPD
时间窗: 9 months
1) To assess the prognostic value of NLR in predicting in-hospital mortality in patients with
时间窗: 9 months
2) To assess prognostic value of PLR in predicting in-hospital mortality in patients with acute
时间窗: 9 months
次要结局
- 1) To analyze the association between Neutrophil to Lymphocyte Ratio (NLR) and(specific clinical outcomes, such as the duration of hospital stay, need for intensive)