THE ROLE OF NEUTROPHIL TO LYMPHOCYTE RATION ,PLATELET TO LYMPHOCYTE RATIO, SERUM LACTATE IN EXACERBATION OF COPD

Not yet recruiting

Conditions: Diseases of bronchus, not elsewhere classified,

Registration Number: CTRI/2025/06/089470

Lead Sponsor: Department of respiratory medicine

Brief Summary: Patients admitted with the diagnosis of AECOPD

satisfying inclusion and exclusion criteria during the study period will be included, socio socio-

demographic and clinical data of patients will be collected and recorded in case proforma upon

admission. Details of comorbidities will be obtained from clinical notes. Breathlessness will be graded

according to the modified Medical Research Council dyspnea (MMRC) score and patients will be

divided in based on group A, B, E. History of smoking, Occupational exposure to smoke, Family

History of COPD will be obtained. Routine investigations like CBC, ABG, chest radiograph at the time

of admission will be done as a standard of care and results shall be recorded in the case proforma. The

patient will be followed up during the entire hospital stay. Clinical Outcomes will be categorized as

ICU admission, duration of admission, mortality. Later the NLR, PLR and serum lactate levels at the

time of admission will be correlated with the clinical outcome of the patient. Lactate level blood (ABG)

test will be considered as a standard care of test in patient of acute Exacerbation of COPD

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 114

Inclusion Criteria

All patients above 18 years of age All patients who are diagnosed case of COPD.

Exclusion Criteria

Patient diagnosed with Bronchial Asthma Patient Diagnosed with Bronchiectasis Patient Diagnosed with Active pulmonary Tuberculosis Patient diagnosed with Malignancy.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
exacerbation of COPD	9 months
3) To assess the prognostic value of lactate levels in predicting in-hospital mortality in	9 months
patients with acute exacerbation of COPD	9 months
acute exacerbation of COPD	9 months
1) To assess the prognostic value of NLR in predicting in-hospital mortality in patients with	9 months
2) To assess prognostic value of PLR in predicting in-hospital mortality in patients with acute	9 months

Secondary Outcome Measures

Name	Time	Method
1) To analyze the association between Neutrophil to Lymphocyte Ratio (NLR) and	specific clinical outcomes, such as the duration of hospital stay, need for intensive

Trial Locations

Locations (1): Kasturba Hospital
🇮🇳
Udupi, KARNATAKA, India
Kasturba Hospital
🇮🇳Udupi, KARNATAKA, India
Dr Sheetal
Principal investigator
07988753275
sheetalsharma09101997@gmail.com